OMF News February 2017
OMF IS FAST-TRACKING REVOLUTIONARY RESEARCH TO FIND ANSWERS! PLEASE DONATE TODAY!
OMF Update
An Interview with OMF Scientific Advisory Board Director, Ronald W. Davis, PhD
We are resending to you the research update interview with Dr. Ron Davis recorded in his office at Stanford University. We apologize for any confusion. The link has been corrected.
Metabolomics & Genetics Study Update:
University of CA, Davis- New Collaboration
We are happy to announce that OMF and Scientific Advisory Board
member Dr. Robert Naviaux at University of California, San
Metabolomics Validation Study update from Dr. Naviaux:
"We have exceeded our original goal of 110 samples. We have collected 72 samples from females (36 CFS + 36 Controls), and 54 samples from males (28 CFS and 26 Controls). The total in-house is 126 samples. This is a 50% increase in the size of the study from our 84 samples in study #1."
The aims of the OMF Metabolomics Validation Study are:
1. Biological replication
2. Analytical replication
Update on Genetics component of the study from Dr. Davis:
Our lab has received immune cells from the patient samples of Dr. Naviaux’s metabolomics study. We will conduct extensive DNA sequence analyses looking for alterations in the sequence that indicate decreased functioning of genes that might correlate with the variations in the metabolic results. The goal is to determine if some of the differences in metabolites seen between patients can be explained by genetic differences. This analysis may explain some of the varied symptoms experienced by patients. It is possible that what appear to be subtypes of this disease are caused by genetic differences interacting with a basic metabolic process. There could be a fundamental mechanism common to all ME/CFS patients. We would like to find a treatment that impacts a fundamental mechanism.
From UCSD: The biological replication will come from the metabolomic analysis of the independent cohort of patients with ME/CFS using the mass spec methods developed at UCSD as in the first paper. All patients have been collected and testing has commenced. This will take 4-6 months (hopefully sooner).
From UCD: The analytical replication will come from a replicate analysis of the same samples using similar mass spectometry methods running the same tests by Dr. Oliver Fiehn’s team at UCD - OMF has funded this study as well and it will commence in March.
The results from UCD will be compared to the first and second metabolomics study and all should be completed by July. This testing will be blinded without reviewing results from Dr Naviaux's validation study until completed. Dr. Fiehn will receive de-identified samples and will be using the same methodology. Each test that is tested within Dr Naviaux's study will be tested in this study on a similar Mass Spectrometer platform.
About the UC Davis Team:
Director Oliver Fiehn and his team at the West Coast Metabolomics Center (WCMC) are committed to provide research and services conducting research in metabolomic method developments and biomedical applications. Professor Fiehn and his team pioneered developments and applications in metabolomics since 1998 with over 220 publications to date. Professor Fiehn specifically focuses on lipids and primary metabolism in cancer, cardiovascular diseases, diabetes, nutrition and metabolic syndrome projects. The WCMC is dedicated to provide further standardization and higher content in biochemical information through automatic annotation of metabolites and by using a range of chemical and biochemical database identifiers with every report we generate.
OMF Welcomes Jaime Seltzer
In addition, during her tenure Jaime will be helping with research communication and promotion. We are very excited to welcome Jaime to this new role.
OMF Maximizes Our Visit to the
Sundance Film Festival
Maximizing our time in Utah, OMF arranged several meetings to talk about ME/CFS research. Dr. Ron Davis and Linda Tannenbaum met with Scientific Advisory Board members Mario Capecchi, PhD and Baldomero Olivera, PhD together with University of Utah's Kathleen Light, PhD and Alan Light, PhD. Dr. Davis and Linda also had the opportunity to meet with Lucinda Bateman, MD and Suzanne Vernon, PhD of the Bateman Horne Center. Finding answers to help patients is at the forefront of everything we do every day.
Open Medicine Foundation
Tax ID: 26-4712664
Our Mission:
- To support collaborative medical research to find effective treatments and diagnostic markers
- To communicate, engage and inform the patient community.
- To help drive & support scientific meetings for continued global collaboration.
As you read above, OMF's research is making great strides. We are moving forward in identifying potential biomarkers, understanding the mechanisms of ME/CFS and focusing on finding effective treatments and a cure.
From our current major studies we are learning about critical opportunities that need further exploration to find answers.
In order for OMF to move quickly with these investigations, we need the support of the global ME/CFS community to fund new studies. Please consider making a meaningful donation to support research. Every gift, of every size, will help to move us closer to answers.
Thank you being our partner in finding answers.
With hope, Linda
Linda Tannenbaum, CEO/President
Open Medicine Foundation
www.openmedicinefoundation.org
Linda@OpenMedicineFoundation.org
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