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OMF-Dr Davis research update (video!)

Discussion in 'Latest ME/CFS Research' started by Ben H, May 22, 2018.

  1. Ben H

    Ben H OMF Correspondent

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    [​IMG]
    OMF Scientific Advisory Board Director Ronald W. Davis, PhD, Presents
    An Update on ME/CFS Research


    Dear all,

    We are pleased to share another research update by OMF's Scientific Advisory Board director, Ronald W. Davis, PhD, produced by Ashley Haugen at the Stanford Genome Technology Center (SGTC).

    Dr. Davis reviews recent progress made at the SGTC and the plans to ramp up research. Watch the video here.

    Stay tuned for additional exciting announcements coming this week.
    Please donate to continue this critical research.

    With hope for all,

    [​IMG]
    Linda Tannenbaum
    CEO/President

    P.S. For OMF friends living in the EU, UK, Australia or Canada, if you want to continue receiving OMF's news in your inbox and you have not yet re-registered, please sign-up today before we must remove you from our mailing lists.


    Thanks all,


    B
     
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  2. TreePerson

    TreePerson Senior Member

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    Hi @Ben H
    Do you know whether the nano needle will be tested on people with depression in order to exclude the possibility that they give the same reading? It seems very important to me that it is, if it’s to be a marker of illness rather than a marker exclusive to ME/CFS.
     
    Last edited: May 23, 2018
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  3. Spindrome

    Spindrome

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    Thanks for the update Ben,

    Do you know if the nanoneedle predicts severity?
     
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  4. Cam Newton

    Cam Newton

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    Seems like the Mark Davis T-cells, metabolic trap theory, and the Norwegians cylcoME trials are the most promising projects to look forward too.

    Thanks for the update.
     
  5. alkt

    alkt Senior Member

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    I do not want to come across as negative but he seems to need a break perhaps he just doesn't like public speaking hopefully that is the case. being selfish I want him to be healthy and at his best for a long time to come.
     
    Murph likes this.
  6. Ben H

    Ben H OMF Correspondent

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    Yes I agree, I believe it will be cross referenced against a number of diseases. @Janet Dafoe (Rose49) may be able to clarify.


    Hi @Spindrome

    I believe there has been some talk that it may have so far, though I am not sure currently. May be wrong. If @Janet Dafoe (Rose49) sees this, she may be able to clarify.
     
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  7. Ben H

    Ben H OMF Correspondent

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    Hi @alkt

    I’m not sure what you mean/are inferring.


    B
     
  8. alkt

    alkt Senior Member

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    I mean he comes across as being very tired . I could of course be wrong but that is the way his speaking sounds to me .
     
  9. ljimbo423

    ljimbo423 Senior Member

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    Just a couple quotes from the video-

    At 4:20 Ron says- "If we can find a trap (metabolic trap) that's really causing this disease it will be easy to reverse. That would be a cure, not just a treatment".:thumbsup:

    5:25- "We have 4 biomarkers". "Those all look pretty good as a biomarker for ME/CFS". "So far, in the nano-needle every patient shows a clear signal and none of the healthy controls do".

    Jim
     
  10. Ben H

    Ben H OMF Correspondent

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    Ron’s work ethic (not sure that is even the right term for what I mean) is astonishing, I have seen it first hand. Even when not at the lab. He also cares for Whitney in shifts with Janet when he is not working. It would make anyone tired, though I am not sure if he is here as I can’t speak for him. He works so, so hard. ‘Lifestyle’ is probably a better term. Same for Janet.


    B
     
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  11. used_to_race

    used_to_race

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    You know, beyond the binary outcome of "cure" or "no cure", I think this hypothesis is worth exploring. Even if it turns out that there is some driving mechanism that is upstream from any metabolic trap(s), perhaps treating the trap(s) could have a hugely beneficial impact on patient quality of life. I know lots of people on here have gotten some (perhaps transient) benefit from nutritional IVs and metabolic supplements, so if we can improve the efficacy of strategies like this by treating in a systematic, research-based way, it could be a big development... even if it's not a cure. I would also imagine that having research to back up these phenomena would go a long way towards ensuring that insurance will cover any treatments related to metabolic traps, which improves the cost, access, and even safety of such procedures.
     
  12. Gamboa

    Gamboa Senior Member

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    Thanks for this Ben.

    I must have missed something at some point recently. What are the 4 potential biomarkers that he is referring to?

    Thanks
    Claire
     
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  13. Seven (formerly lnester7)

    Seven (formerly lnester7) Seven

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    We the poor have to think outside of the box. What we have extra is very well trained people that can help.
    So maybe we can increase the number of plp by using volunteers ( I would be willing) and like hey right this paper, contact patients.... get the volunteers run the leg work and let the little researcher you have focus on the important things
     
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  14. Gemini

    Gemini Senior Member

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    @Gamboa, I've heard Ron mention 4 but I don't think he's talked in detail about all of them.

    In a recent Science Wednesday update @Ben H posted, the nanoneedle and another device called a "Magnetic Levitation" device that measures density of white blood cells are described. Findings indicate ME/CFS patient's WBC's are less dense than controls. I thought these may be 2 of the 4, perhaps Ben can comment on them?

    Here's the link:

    http://forums.phoenixrising.me/inde...nded-diagnostic-technology-development.59275/
     
  15. Murph

    Murph :)

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    I was trying to think of these. If I had to guess what they are based on everything I've heard:

    1. electrical impedance measurements of mecfs cells exposed to salt stress. [edit: aka the nanoneedle experiment]
    2. a stratification thing where mecfs cells are lighter (?) [edit, the thing @Gemini is mentioning in the post above]
    3. red blood cell shape differences
    4. naviaux's metabolic panel (expensive though)

    Open to disagreements / other suggestions here.
     
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  16. mariovitali

    mariovitali Senior Member

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    Also, Is it logical to assume that "less dense WBC" implies lower count of WBC ?
     
  17. Diwi9

    Diwi9 Administrator

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    I was in Ron Davis' lab on Monday and Tuesday to participate in two studies. My sister accompanied me and the research assistants were excited to be able to include a healthy family member in both studies. If you are traveling to see a specialist in the Bay Area, please consider finding out if there are studies you can participate in while in the area. The research assistants are in need of participants to complete the current studies. Dr. Montoya also has about three studies that are recruiting participants at this time.
     
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  18. Janet Dafoe (Rose49)

    Janet Dafoe (Rose49) Board Member

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    1. Nanoneedle
    2. Magnetic Levitation Device
    3. Deformability of Red Blood Cells
    4. Mitochondrial Function Test using Seahorse instrument
    Also, metabolomics, as in Naviaux's study, but this is very expensive at the moment.

    Stay tuned. More is coming out about 2018 research very soon. We worked on it for hours today and this evening.
     
    AnnaDove, MEssias, Laurie P and 19 others like this.
  19. Janet Dafoe (Rose49)

    Janet Dafoe (Rose49) Board Member

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    I don't think so. I'll try to get back to you, but it might not be really soon as I'm having surgery on Thursday. ::(
     
    AnnaDove, Laurie P, Sushi and 6 others like this.
  20. Janet Dafoe (Rose49)

    Janet Dafoe (Rose49) Board Member

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    Thank you so much! I wish I'd known so I could have had you visit and we could meet. I've had several patients who were donating blood come over and spend some time with me so I can meet them, and I've really enjoyed it. If you're coming, please contact me if you would like to meet! :)
     

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