Oleamide for sleep

[SwanRonson]

Has anyone had experience with Oleamide? I'm thinking of trying this protocol:

https://www.grc.com/health/sleep/healthy_sleep_formula.htm

but I know nothing of Oleamide. I had never even heard of it. Anyone know anything?

 

[Mary]

Has anyone had experience with Oleamide? I'm thinking of trying this protocol:

https://www.grc.com/health/sleep/healthy_sleep_formula.htm

but I know nothing of Oleamide. I had never even heard of it. Anyone know anything?

I've never heard of oleamide either. However, I clicked on the grc link you provided and I am familiar with using niacinamide and melatonin for sleep, which are part of their protocol.

In the last several months I had severe sleep problems due to a lorazepam taper (from 1 mg. to 0.5 mg.) And finally after a lot of experimentation, I came up with a protocol which worked pretty well. It's a lot of stuff, but I didn't want to take any more drugs. I briefly tried trazodone and it made me very tired and fuzzy, even at quite small doses.

So this is what I came up with for sleep. I don't recommend someone take all of this to begin with, it's quite a bit, but perhaps smaller of doses of everything until you see what works (or doesn't):

an hour before bed:

150 mg. 5-htp
2000 mg. glycine
500 mg. niacinamide or 1000 mg. niacin
200 mg. l-theanine
3 mg. melatonin (Natrol sublingual)
500 mg. inositol

In the middle of the night, repeat everything except no more 5-htp

5-htp helps produce serotonin so in general should not be combined with an SSRI.

Niacinamide is supposed to be more effective at stimulating GABA receptors than plain niacin; however, niacin seems to work better for me. At my worst, I took both niacin and niacinamide, but am trying to just use niacin now. If you take niacin, the plain kind that makes you flush is best. Extended or time-release niacin has been linked to liver damage.

If you do try oleamide, let us know how it goes.

 

[SwanRonson]

Extended or time-release niacin has been linked to liver damage.

Does the same thing apply to Niacinamide?

 

[helen1]

@SwanRonson
I bought some oleamide a few months ago from Liftmode. It's derived from olive oil and works on the same receptors as cannibidiols. I found it helped with sleep for the first few weeks then the effect ended. I've stopped using it mostly. I had no bad side effects though.

 

[Mary]

Does the same thing apply to Niacinamide?

I don't know. A brief search turned up lots of hits for time-release niacin and liver damage, but not niacinamide. In general I avoid time-release any kind of supplement. I read once years ago they're just generally not a good way to go, but I can't give you the reasoning.

 

[rebar]

I tried it , didn't work for me. Didn't notice any effect. Tried all of Mary's list no go for me. I'm now on L-tryptophan, about 2g, and when I wake at 12 to 1 or so I take half of a 10mg ambien. I get 5 to 6 hour a night, usually closer to 5. It's been a particularly difficult problem for me, for over a year, 3 hours a night for 4 or 5 months straight. I took seroquil for years and it worked like a charm but stopped because of it's anticholinergic effect and my fear of it contributing to memory issues. Although I'm not crazy about taking ambien, I've not yet found a substitute. I too continue to search and try things.

 

[rebar]

Also as Helen mentioned the Liftmode site, good products and information.

 

[invisiblejungle]

I tried Liftmode's oleamide, up to 1 gram, but it never had any effect on sleep for me. Worth trying though!