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Of mice and prostate tumor

natasa778

Senior Member
Messages
1,774
The issue of mice not developing prostate tumors came up on few threads recently. I just came across this and thought it was interesting (wasn˙t sure where to post hence a new thread...)

As I mentioned previously, there's several papers that I want to blog about right now but I have been too busy writing grants and papers. But as another paper goes off today, I am going to write about this really awesome work that was published a couple of weeks ago by Sam Denmeade and John Isaacs, and their collaborators. Sam and John are at Hopkins, and have been working on targeting PSMA for a very long time - Let me digress for a minute and give some of the background - PSMA is an abbreviation for Prostate-Specific Membrane Antigen, but the term is somewhat a misnomer as it is expressed in a variety of tissues.

... Dean Bacich - at the time a postdoc in Skip's lab at Sloan made several types of PSMA transgenic mice - mice don't normally express PSMA in the prostate so Dean engineered the mice so that they expressed moderate levels (equivalent to humans) in the prostate epithelial cells. These mice got what is considered the precursor to prostate cancer, PIN, suggesting that PSMA expression can cause or promote cancer, and later he showed that if the mice lived as long as humans, it would have been cancer...

http://okeefe-lab.blogspot.co.uk/2012/07/psma-as-therapeutic-target-for-most.html

http://stm.sciencemag.org/content/4/140/140ra86.short