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Novel Retrovirus Diagnostic Test Developed

Discussion in 'XMRV Testing, Treatment and Transmission' started by shannah, May 6, 2010.

  1. shannah

    shannah Senior Member

    Found this posted over at the Prohealth Board. Something about this article seems vaguely familiar yet it's dated yesterday. Is this new?

    Science Magazine

    Wednesday, May 5th, 2010

    Correlation Between XMRV and Prostate
    Cancer: Novel Retrovirus Diagnostic Test

    An article published in the April issue of Urology is
    a step in this direction as researchers from Emory
    University report the successful development of an
    experimental clinical test for XMRV.

    "We cannot as a scientific community begin to
    answer the basic questions of XMRV transmission,
    frequency in the population, association with
    disease, etc. until we can effectively test for

    according to lead investigator John A. Petros, MD,
    Associate Professor of Urology, Emory University
    School of Medicine and Veterans Administration

    Dr. Petros and co-investigators adapted technology
    developed in the HIV arena (neutralizing antibody
    assay) and have developed a serum test that can
    identify patients who have previously been infected
    with the virus.

    This assay has been rigorously confirmed by two
    independent labs and two independent technologies
    (PCR and FISH), thus confidence in the accuracy of
    the test is high.

    The mode of transmission
    of the virus is unknown.

    No method is available to screen either blood or
    tissue donors for infection and no data are available
    regarding whether the virus can be transmitted by
    blood transfusion or tissue transplantation.

    Dr. Petros comments:

    "The public deserves to know if the next blood
    transfusion or organ donation will give them XMRV
    retrovirus, an infection which lasts for life, and could
    possibly be related to prostate cancer. The failure to
    develop accurate tests for this virus is a serious
    public health oversight."

    Although the assay used in the present report
    involved the inhibition of infection of target cells by
    viral-like particles with the XMRV envelope protein
    expressed on their surface, results also suggest that
    more standard serologic tests for antibodies against
    specific viral antigens can be developed in the

    The authors conclude that:

    "our report adds to the growing body of evidence
    that XMRV is indeed a novel gamma-retrovirus
    capable of infecting humans and that at least some
    patients with prostate cancer have been infected
    with XMRV.

    We have reported serologic evidence of infection and
    that the serology correlated with tissue-based

    The concordance of 3 independent methods of
    detecting infection added confidence to the assertion
    that this recently discovered virus is real and
    possibly related to human disease.

    Robust clinical assays are needed to detect XMRV
    infection, and much work remains to be done in
    determining whether XMRV is indeed an oncogenic
    virus or simply an associated epiphenomenon. "

    Source: Adapted from materials provided by Elsevier
    Health Sciences, via EurekAlert!, a service of AAAS.
  2. usedtobeperkytina

    usedtobeperkytina Senior Member

    Clay, Alabama
    Great news. This is what I have been waiting for. Verified with two other labs. Two different ways to check for it.

    Is this the study that was announced that involved Emory that had many different labs with many different samples and whoever finds it most accurately wins? So the results of that study are already out?

    Makes sense to use prostate cancer patients. You can test the blood assay accuracy against known XMRV+ people as far as their prostate tissue.

    But this will help us too.

    What's next? FDA approval? Labcorps, Quest, hello, is anyone out there. You have an opportunity. Here is the contact info at Emory:

    Ashante Dobbs: 404-727-5692

  3. Rivotril

    Rivotril Senior Member

    Great news! don't know if there's another topic on this yet, because i found out that the news is from april 6th 2010:
    for me it also sounded a bit familiar...but lately there's so much going on in the ME/CFS scene that sometimes it's hard to be familiar with all the news... but that's only a good thing, because most of them are positive developments
  4. Hope123

    Hope123 Senior Member

    I think this has been posted before.....back in April.....but it's always interesting to read another article. I think this might be related to the monkey studies at Emory (where they used FISH and tissue samples) and developed an antibody test with Abbot that found about 0.1% of a sample of blood donors (like 3/3000) were XMRV+.
  5. usedtobeperkytina

    usedtobeperkytina Senior Member

    Clay, Alabama
    well, if Emory has already declared they have an independently verified accurate test, why do we have that other assay study that is looking for the reliable test?

    Is it me or is it them? (This reminds me of the Martin Short in the character Nathan Thurm. One of his sayings was, "Is it me or is it him?") (this doesn't apply directly, but it is hilarious.)
    Wouldn't it be interesting to see an interview with this guy on the hot seat like this?


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