Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data
The Microbe Discovery Project outlines an ambitious new study by top researchers that has collected patient samples, but needs desperately funds to complete the work.
Discuss the article on the Forums.

No response from high dose B12 & Methylfolate...what am I missing?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Bluelude1, Jan 30, 2018.

  1. Bluelude1


    I have spent the last couple of months researching and going through my understanding of methylation and my supplement forms/dosing with a fine tooth comb and my conclusion is I am still missing SOMETHING.

    The crux of the problem seems to somewhat center around the fact that I don't respond to B12 or Methylfolate hardly at all. I feel nothing with 30mg of MeCbl (Jarrow), 50mg of AdoCbl (Source Naturals) or 30mg of Methylfolate (Solgar). FWIW - I am taking the B12 sublingually as intended.

    I've taken between 10-30mg of Methylfolate a day for the last 3-4 months with negligible effect. To be fair though I didn't realize until somewhat recently that I needed to take more MeCbl than I took folate, and since I never felt it one way or another when I took MeCbl I wasn't always consistent with taking a high enough dose of MeCbl.

    My blood pressure and pulse have stayed almost frustratingly stable 120s/80s with a 75-85bpm pulse. With no need for supplemental potassium.

    Couple of factors
    1.) Last time I actually had my serum levels of B12 checked, several years ago, I was off the charts (>1999) and my folate levels were similarly about double the upper limit. So there is something potentially off there

    2.) A couple of weeks ago I realized, when I went back and looked after reading about methylation roadblocks, that my lithium levels in my hair test were below the lowest value on the test, so I added the 10mg of lithium.

    3.) My dad has done virtually the exact same things and has an almost identical response, where as my mother can take 400mcg of methylfolate and definitely feels it. So there could possibly be some genetic factor at play.

    Current Supplements:
    Vitamin A - 50,000 IU
    Vitamin D3 - 8,000 IU
    Vitamin E - 400 IU

    Vitamin B1 Benfotiamine - 600mg
    Vitamin B2 (sublingual FMN) - 18.6mg
    Vitamin B5 (Pantethine) - 450mg
    Vitamin B6 (P5P) - 100mg
    Biotin - 30,000mcg

    Zinc Picolinate - 100mg
    Magnesium Glycinate - 600-800mg
    Selenium - 200mcg
    Molybdenum - 2000mcg
    Manganese - 50mg
    Boron - 9mg
    Kelp - 1800mg
    Lithium Orotate - 10mg

    TMG - 2,400mg
    Taurine - 2,000mg
    Creatine HCL - 2.5g
    MSM - 8g
    Vitamin C - 500mg
    DIM - 100mg
    L-Carnitine Fumerate - 1000mg​

    I could potentially see not responding to B12 with sky-high serum levels, but not feeling anything from up to 30mg of methylfolate taken over an extended period has me perplexed.

    Is there anything you can see that I would possibly be missing?
    Last edited: Jan 31, 2018
  2. aaron_c

    aaron_c Senior Member

    Those are really high levels of methylfolate and methylcobalamin. I'm a bit concerned that, if you do find that last crucial ingredient, you'll have a pretty dramatic response that could, particularly in terms of potassium, get dangerous.

    That said, I see you don't list carnitine. I know Freddd regarded carnitine as an essential part of his protocol. As I recall, he seemed to think that different people would find different forms of carnitine to be the most beneficial. The forms I know of are L-Carnitine, Acetyl L-Carnitine (ALCAR), and Carnitine Fumarate, so you might want to try some or all of those.
  3. mattie


    There are many PWME who do not respond to this approach at all. I am one of them. It certainly does not mean you are doing it wrong or that you are missing something.
    Helen and jpcv like this.
  4. jpcv

    jpcv Senior Member

    SE coast, Brazil
    Many patients don´t respond at all, probably because methylation has nothing to do with their disease
    Mel9, Helen and mattie like this.
  5. Bluelude1


    I know what you mean. I had a similar experience a couple of years ago when I was working on methylation and finally got things to "click" and started to overmethylate. Fortunately, I have a much better understanding of how to reign it in now.

    Good catch, I am actually taking 1000mg L-Carnitine Fumarate and I updated my above list to reflect that.

    I could understand not responding to additional B12 if levels are sufficient, but its that fact I don't respond to the methylfolate (especially at such a high dose) that has me perplexed.
  6. PatJ

    PatJ Forum Support Assistant

    There were a lot of unhappy people several years ago when Jarrow changed the formula for their MB12 and it became ineffective for many individuals. If Jarrow is still using the same formula then it might explain why you don't notice anything.

    Freddd recommended Enzymatic Therapy as the best quality in an oral supplement but you would need to take a bottle per day at your current dose since they only come in 1mg tablets, 30 per bottle. Country Life has 5mg tablets that were also recommended and would be more economical.
    aaron_c and matt3n like this.

See more popular forum discussions.

Share This Page