I have spent the last couple of months researching and going through my understanding of methylation and my supplement forms/dosing with a fine tooth comb and my conclusion is I am still missing SOMETHING. The crux of the problem seems to somewhat center around the fact that I don't respond to B12 or Methylfolate hardly at all. I feel nothing with 30mg of MeCbl (Jarrow), 50mg of AdoCbl (Source Naturals) or 30mg of Methylfolate (Solgar). FWIW - I am taking the B12 sublingually as intended. I've taken between 10-30mg of Methylfolate a day for the last 3-4 months with negligible effect. To be fair though I didn't realize until somewhat recently that I needed to take more MeCbl than I took folate, and since I never felt it one way or another when I took MeCbl I wasn't always consistent with taking a high enough dose of MeCbl. My blood pressure and pulse have stayed almost frustratingly stable 120s/80s with a 75-85bpm pulse. With no need for supplemental potassium. Couple of factors 1.) Last time I actually had my serum levels of B12 checked, several years ago, I was off the charts (>1999) and my folate levels were similarly about double the upper limit. So there is something potentially off there 2.) A couple of weeks ago I realized, when I went back and looked after reading about methylation roadblocks, that my lithium levels in my hair test were below the lowest value on the test, so I added the 10mg of lithium. 3.) My dad has done virtually the exact same things and has an almost identical response, where as my mother can take 400mcg of methylfolate and definitely feels it. So there could possibly be some genetic factor at play. Current Supplements: Vitamin A - 50,000 IU Vitamin D3 - 8,000 IU Vitamin E - 400 IU Vitamin B1 Benfotiamine - 600mg Vitamin B2 (sublingual FMN) - 18.6mg Vitamin B5 (Pantethine) - 450mg Vitamin B6 (P5P) - 100mg Biotin - 30,000mcg Zinc Picolinate - 100mg Magnesium Glycinate - 600-800mg Selenium - 200mcg Molybdenum - 2000mcg Manganese - 50mg Boron - 9mg Kelp - 1800mg Lithium Orotate - 10mg TMG - 2,400mg Taurine - 2,000mg Creatine HCL - 2.5g MSM - 8g Vitamin C - 500mg DIM - 100mg L-Carnitine Fumerate - 1000mg I could potentially see not responding to B12 with sky-high serum levels, but not feeling anything from up to 30mg of methylfolate taken over an extended period has me perplexed. Is there anything you can see that I would possibly be missing?