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Nisin fights gram-positive bacteria / cancer

Discussion in 'Other Health News and Research' started by roller, Jan 13, 2016.

  1. roller

    roller wiggle jiggle

    'Magic MOLD' could wipe out two lethal conditions: Natural preservative that grows on dairy products 'kills cancer cells and antibiotic-resistant bacteria'
    • Nisin is a naturally-occurring food preservative found on dairy products
    • And, a study revealed it can wipe out cancer cells and bacteria
    • Scientists tested nisin on tumors and as an antimicrobial in rats
    • After nine weeks of treatment, 70-80% of cancer cells were killed off
    • And, no bacteria has been found to be resistant to the effects of nisin
    PUBLISHED: 17:22 GMT, 12 January 2016 | UPDATED: 17:38 GMT, 12 January 2016

    Scientists have long searched for new, more effective treatments to tackle cancer.

    But, a new study suggests, the answer may have been lurking in dairy products the whole time.

    Nisin – a naturally occurring food preservative that grows on daily products – can wipe out cancer cells and it can also combat antibiotic-resistant bacteria, scientists said.

    University of Michigan researchers studied the effect of nisin on cancerous tumors and as an antimicrobial to fight diseases in the mouth.

    After nine weeks of treatment, they found that the tumors had shrunk significantly and were comparable to tumors at three weeks.

    Dr Yvonna Kapila, a professor at the University of Michigan School of Dentistry, said: ‘To date, nobody had found bacteria from humans or living animals that is resistant to nisin.’


    Nisin is a naturally occurring food preservative that grows on dairy products. A new study revealed this 'magic mold' can wipe out cancer cells and antibiotic-resistant bacteria

    The scientists found feeding rats a ‘nisin milkshake’ killed 70 to 80 per cent of head and neck tumor cells after nine weeks – and extended survival rates.

    The team previously published positive results with less potent nisin.

    However, the highly purified nisin ZP used in the current study nearly doubled its effectiveness, they found.

    They gave a dosage of 800 mg/kg to mice – which would translate to a pill larger than a third of an Advil per kilogram of body weight for humans.

    Nisin is a colorless, tasteless powder that is typically added to food at a rate of .25 to 37.5 mg/kg.

    While many foods contain nisin, none contain anywhere near the 800 mg/kg needed to kill cancer cells.

    Additionally, there are several consumer products that contain nisin – such as creams and pharmaceuticals to combat infection and mastitis, as well as a sanitizer in lactating cows.

    The results are promising, but scientists stress that that it’s too early to say if nisin will act the same way in humans.

    In addition to their findings regarding cancer, the scientists found nisin fights deadly bacteria, including antibiotic-resistant MRSA.

    In a recent paper, they looked at experimental uses of nisin to treat 30 different types of cancer; infections of the skin, respiratory system and abdomen; and oral health.

    Nisin is lethal to bacteria for two reasons. First, it binds to a static area of bacteria.

    That gives nisin the chance to work before bacteria changes into an antibiotic-resistant superbug.


    Scientists found feeding rats a ‘nisin milkshake’ killed 70-80 per cent of head and neck tumor cells after nine weeks. Also, nisin has been shown to fight deadly bacteria, including antibiotic-resistant MRSA (pictured)

    Secondly, it kills biofilms, which are colonies of bacteria that group together in a fortress that blocks antibiotics.

    The scientists noted that nisin has ‘withstood the test of time'.

    Dr Kapila said: ‘Mother Nature has done a lot of the research for us, it’s been tested for thousands of years.’

    Next, the team hopes to test nisin in a clinical setting.

    Dr Kapila said: ‘The application of nisin has advanced beyond its role as a food biopreservative.

    ‘Current findings and other published data support nisin’s potential use to treat antibiotic resistant infections, periodontal disease and cancer.’

    The study was published in Journal of Applied Microbiology.

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  2. Kati

    Kati Patient in training

    And now everybody will go buy that with the secret hope they will be cured tomorrow.
    maryb likes this.
  3. adreno

    adreno PR activist

    I think I prefer bacteria over mold.

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