I experimented with hydergine last fall (OK, OK, I took it twice, LOL) but it wasn't a miracle for me. I read about it's effects in Dr Goldstein's book and it looked like a reasonable thing to try. Now I'm curious if maybe this related drug, nicergoline, is a better fit for MECFS than hydergine anyway. Since some POTS patients may have antibodies to the a-1 adrenoceptors, it seems like it might help for that as well in a subgroup. I'm also interested in the possibility of boosting nerve growth factor, which is how I stumbled upon it. It seems like boosting nerve growth factor can calm down the glial cells too. Has anyone tried it? It looks to be OTC in some countries, but of course not here in the US.