Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results
Big cohort, detailed look at Natural Killer cells and T cell subsets, looks at long non-coding RNAs too
Our Specific Aims are:
1) To determine the frequencies of immune cell subsets in the blood of a
clinically defined ME/CFS patient cohort;
2) To assess functional capacity of memory T cells, innate cells and the differentiation potential of naive T cells during ME/CFS; and
3) To determine the T cell and innate cell subset–specific gene and lncRNA transcripts in ME/CFS patient blood samples.
Our goal is to develop a detailed functional and genetic immunological framework that can be used to
i) decode the mechanisms of ME/CFS [hah, ambitious!] and
ii) to develop robust, quantitative immune-biomarker sets for predicting disease susceptibility, stratifying patients and guiding treatment strategies.
We have assembled a unique team of experts in human immunology, clinical ME/CFS biology for well-defined patient samples, non-coding RNAs, transcriptomics and bioinformatics, together will contribute to the deep and complimentary expertise necessary to bring about this goal.
