Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data
The Microbe Discovery Project outlines an ambitious new study by top researchers that has collected patient samples, but needs desperately funds to complete the work.
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Newly discovered gut organism protects mice from bacterial infections

Discussion in 'Other Health News and Research' started by adreno, Oct 8, 2016.

  1. adreno

    adreno PR activist

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    http://medicalxpress.com/news/2016-10-newly-gut-mice-bacterial-infections.html
     
  2. natasa778

    natasa778 Senior Member

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    This, or rather its absence, could be why synthetic poo trials are not working as expected/hoped. Still very early days but the effects so far are apparently not nearly as exciting as the real mccoy fecal transplants.
     
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  3. alicec

    alicec Senior Member

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    How exciting that we now have the tools to fully explore the gut microbiome and its host interactions.

    The study reminds me of the people suffering from inflammatory bowel disease who deliberately infected themselves with hookworm in a desperate attempt to relieve the distressing symptoms. It seemed to work.

    The parasites managed to control the out of control inflammatory response when nothing else could.

    And what of current thinking that D. fragilis (the mouse prolist is an ortholog of this organism) in the gut needs to be wiped out with antibiotics?
     
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  4. adreno

    adreno PR activist

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    My thoughts exactly. It is also another reminder of how much we need Lipkins research. It could well be found that certain protists are missing in PWME.
     
  5. adreno

    adreno PR activist

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    The tools are there. Now if we could only get the funding...
     
  6. adreno

    adreno PR activist

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    The abstract from the study. It seems there is a downside to this enhanced immunity:
    http://dx.doi.org/10.1016/j.cell.2016.08.076
     
  7. alicec

    alicec Senior Member

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    Yes, as Martin Blaser has pointed out in his studies of the protective role of Helicobacter pylori, this ancient organism which we in the west are losing from the gut (not to mention actively killing off with antibiotics any time it is detected) appears to have protected us from things like asthma and allergies.

    The price that a few have paid is increased susceptibility to ulcers and stomach cancer, though this may apply to only a few strains of the organism.
     

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