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New study showing how LPS triggers immune response

Discussion in 'Other Health News and Research' started by Effi, Jul 4, 2016.

  1. Effi

    Effi Senior Member

    Dectin-2 recognises mannosylated O-antigens of human opportunistic pathogens and augments lipopolysaccharide activation of myeloid cells
    1. Alexandra Wittmann1,
    2. Dimitra Lamprinaki1,
    3. Kristian M. Bowles2,
    4. Ewa Katzenellenbogen3,
    5. Yuriy A. Knirel4,
    6. Chris Whitfield5,
    7. Takashi Nishimura6,
    8. Naoki Matsumoto6,
    9. Kazuo Yamamoto6,
    10. Yoichiro Iwakura7,
    11. Shinobu Saijo8 and
    12. Norihito Kawasaki1*
    First Published on June 29, 2016
    doi: 10.1074/jbc.M116.741256jbc.M116.741256.

    Article on the paper: http://www.ifr.ac.uk/news/latest-news/2016/07/new-insights-how-we-fight-bacterial-infection/
    Justin30, alkt, rosie26 and 7 others like this.
  2. Groggy Doggy

    Groggy Doggy Guest

    "Whilst the lipid part is relatively similar between different bacteria, the polysaccharide is highly variable"

    @Effi I like this research, a true international effort. It's very interesing and I hope future research will reveal what causes the variability.
    Justin30, alkt and Effi like this.
  3. Justin30

    Justin30 Senior Member

    It would be be very beneficial for a standardized test to show the amount of LPS in blood serum.

    This being said CD14 is a marker for LPS but is not readily used.

    Further drugs that are safer in the reduction of LPS in serum need to be developed to tackle this problem as LPS seems to interefere with many biological process such as the breakdown of vitamins, minerals and amino acids.

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