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New Rituximab study results published!

Discussion in 'Rituximab: News and Research' started by Joolz, Jul 1, 2015.

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  1. Joolz

    Joolz

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    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129898

    "Major or moderate responses, predefined as lasting improvements in self-reportedFatigue score, were detected in 18 out of 29 patients (intention to treat). Clinically significant responses were seen in 18 out of 28 patients (64%) receiving rituximab maintenance treatment. For these 18 patients, the mean response durations within the 156 weeks study period were 105 weeks in 14 major responders, and 69 weeks in four moderate responders. At end of follow-up (36 months), 11 out of 18 responding patients were still in ongoing clinical remission. For major responders, the mean lag time from first rituximab infusion until start of clinical response was 23 weeks (range 8–66). Among the nine patients from the placebo group in the previous randomized study with no significant improvement during 12 months follow-up after saline infusions, six achieved a clinical response before 12 months after rituximab maintenance infusions in the present study. Two patients had an allergic reaction to rituximab and two had an episode of uncomplicated late-onset neutropenia. Eight patients experienced one or more transient symptom flares after rituximab infusions. There was no unexpected toxicity."
     
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  2. funkyqueen

    funkyqueen Senior Member

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    South of France
  3. deleder2k

    deleder2k Senior Member

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    Finally! I have been waiting for this way too long!
     
  4. Scarecrow

    Scarecrow Revolting Peasant

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    Scotland
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