Discussion in 'General Treatment' started by Ember, Jul 16, 2012.
KONA, Hawaii, July 16, 2012
I was curious about the cohort selection because I wish I had the $$ back I spent on this stuff. I know it's an important part of some nutritional protocols that are helping people, but on it's own, I'm skeptical.
I think going by the PACE trial it is fair to discount as fairly worthless any research that is un-blinded, with no comparable placebo control and subjective measures.
It seems particularly lazy methodology in this case considering how easy it would have been for them to have blinded the trial and given half of the participants 5g of something inert 3 times a day as a control.
A real lasting improvement or a temporary improvement followed by a massive crash? 25 days seem very short to me...
What about some other people on here, including myself, where D-Ribose had no effect? I would think we would even know if we had a 25% increase in energy levels. Goes to show that anyone can respond differently to supplements. I think it's great though for people who get a positive response to D-Ribose.
Also, unless Cheney has changed his tune on D-Ribose, which I don't know if he has or hasn't, atleast according to this he says....
"CFS is a problem of energy - and d-Ribose won’t help. It just makes the problem worse. He says the same thing about co-Q-10."
So, if he hasn't changed his mind, I guess the debate goes on.
Does Teitelbaum profit off of the sale of D-Ribose? Once again, I think it's great some people get a good response from it.
I have just tried this and stopped it again rather quickly as I was getting terrible bloating/gas. I also noticed that the dermatitis on my palms had returned, after almost completely disappearing following a few weeks of a gut alkalising regime, which I started after reading the very credible evidence of benefit from this. (I've contributed here to a thread on this.) My blood pressure also shot up despite my medication for it. It's going down again now. I'm pretty annoyed that my progress has apparently been set back by this supplement, and want to warn others.
Having just quickly looked at Dr Teitelbaum's and Dr Sarah Myhill's info on d-ribose I got the impression that it would help and was pretty free from side effects. Since getting apparent adverse effects myself I did some online searching today and found the following from scientific papers:
1. It can cause sudden rises in insulin and marked and prolonged drops in blood sugar.
2. In some people it causes increased levels of lactic acid/lactate in the blood. People with ME are already thought to produce too much lactate in the muscles during exertion - it's one of the causes of the muscle pain.
3. D-ribose can also cause increases in uric acid, which can have a number of adverse consequences.
You can see the evidence here if you can follow scientific language:
and Dr Teitelbaum's site does sell d-ribose as well as other things he recommends, citing his own evidence. This has to give rise to at least some caution.
DRibose, CoQ10, l carnitine and others work together very well. I use them daily. My CFS is not a problem now. I would surely not stop CoQ10, too many benifits.
MeSci, great finds on the links. Gosh, Teitelbaum sells D-Ribose...surprise surprise LOL.
I'm taking D-ribose in the form of BioEnergyC. I'm getting about 2g of D-ribose per day (about 1 tsp spread out over the day). I tolerate it well. It helps energy about 3%, but that's enough to go from "warmed over death", to feeling sort of ok as long as I don't push it.
I've taken more in the past, but it didn't help any more.
I'd go with CoQ10 and l-carnitine, no problem, Can't afford them at the moment but am taking l-glutamine, which may be a good adjunct to the others.
I periodically have taken D-Ribose and have seen benefits. It definitely helps with mental clarity and energy. The last week really drained me and yesterday was a completely useless day. I took some D-Ribose during the night and felt quite a bit better this morning.
Since I take so many supplements, I just can't take them all every day. Ubiquinol and SAMe are must haves for me. NAC is also beneficial. So many supplements - way too expensive! They do help though.
I agree, I take SO many supplements, but they are priceless!
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