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New molecule BX795 clears latent HSV-1 from cultured infected cells

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Wonkmonk, Apr 16, 2018.

  1. Wonkmonk

    Wonkmonk Senior Member

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    "[A] small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV-1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV-1. [...] Additionally, the concentration of BX795 needed to clear HSV-1 infection is quite low. We saw clearance of the virus at concentrations of BX795 that were five times lower than concentrations of antiviral compounds in available nucleoside analogs, Shukla said. [...] Because BX795 targets a common pathway that many viruses use to replicate inside the cell, it could be a new kind of broad-spectrum antiviral that might be used to treat other viral infections. [...] Because of BX795's low toxicity, it has a great potential for systemic use as well as topical application."

    https://www.sciencedaily.com/releases/2018/02/180215110339.htm
     
    Sancar, Hip, junkcrap50 and 4 others like this.
  2. BadBadBear

    BadBadBear Senior Member

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    Wow! That would be an amazing advancement, esp. if its truly not very toxic. Good article, @Wonkmonk
     
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  3. nanonug

    nanonug Senior Member

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    That is great news if usable by humans!
     
  4. Hip

    Hip Senior Member

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    BX795 is also a PDK1 inhibitor, which might be useful in ME/CFS given, that Fluge and Mella found significant upregulation of PDK1, PDK2, and PDK4 in PBMCs from ME/CFS patients.
     
    Last edited: Apr 16, 2018
  5. nanonug

    nanonug Senior Member

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    I believe it's a "different" PDK1, namely, phosphoinositide-dependent kinase-1.
     
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  6. Hip

    Hip Senior Member

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    Ah right, well spotted. I'll strike out my above comment to prevent any misunderstanding.
     
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  7. Wonkmonk

    Wonkmonk Senior Member

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    Sidny likes this.

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