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New molecule BX795 clears latent HSV-1 from cultured infected cells

Discussion in 'Antivirals, Antibiotics and Immune Modulators' started by Wonkmonk, Apr 16, 2018.

  1. Wonkmonk

    Wonkmonk Senior Member

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    "[A] small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV-1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV-1. [...] Additionally, the concentration of BX795 needed to clear HSV-1 infection is quite low. We saw clearance of the virus at concentrations of BX795 that were five times lower than concentrations of antiviral compounds in available nucleoside analogs, Shukla said. [...] Because BX795 targets a common pathway that many viruses use to replicate inside the cell, it could be a new kind of broad-spectrum antiviral that might be used to treat other viral infections. [...] Because of BX795's low toxicity, it has a great potential for systemic use as well as topical application."

    https://www.sciencedaily.com/releases/2018/02/180215110339.htm
     
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  2. BadBadBear

    BadBadBear Senior Member

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    Wow! That would be an amazing advancement, esp. if its truly not very toxic. Good article, @Wonkmonk
     
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  3. nanonug

    nanonug Senior Member

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    That is great news if usable by humans!
     
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  4. Hip

    Hip Senior Member

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    BX795 is also a PDK1 inhibitor, which might be useful in ME/CFS given, that Fluge and Mella found significant upregulation of PDK1, PDK2, and PDK4 in PBMCs from ME/CFS patients.
     
    Last edited: Apr 16, 2018
  5. nanonug

    nanonug Senior Member

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    I believe it's a "different" PDK1, namely, phosphoinositide-dependent kinase-1.
     
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  6. Hip

    Hip Senior Member

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    Ah right, well spotted. I'll strike out my above comment to prevent any misunderstanding.
     
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  7. Wonkmonk

    Wonkmonk Senior Member

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  8. Sidny

    Sidny

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    Did you conclude whether this was available for public purchase? Has any one heard of the substance being used to self treat?
     
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  9. Wonkmonk

    Wonkmonk Senior Member

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    No, I don't have any further information. From what I know I'd conclude that (a), it's safety is not established and (b), it can only be obtained from labs if you can prove you are making a clinical trial or other research, so you'd need to be or know a doctor or scientist to obtain it.

    But what's interesting, this newer article says the following:

    "BX795 works by blocking viral protein synthesis through Akt, a host cell molecule required to start protein synthesis."

    https://www.precisionvaccinations.com/bx795-reduces-herpes-virus-treating-hsv1-infections-eye

    It was discussed in another thread that miltefosine also inhibits Akt and there are studies who showed the effectiveness against Herpes Simplex in vitro. Miltefosine is approved against Leishmaniasis, is available with prescription and from what I know is reasonably safe.

    That said, however, @Hip opined that because of the strong affinity to plasma bonding, miltefosine might not reach sufficient intracellular concentrations. But I am still thinking about trying it, just to see what happens.
     
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