Hi all, I'm relatively new to this board, though I was here briefly, many years ago. I've been sick for ages (30 years or so) and had long ago given up finding out what was wrong. Luckily my case is mild compared to some, so I've always been functional at a somewhat low level, though it's been very hard to support myself. Anyway, I recently came out of my shell again to poke around and see if anything new is on the horizon and, lo and behold, came across information on methylation and mitochondrial dysfunction. I ended up running a Genetic Genie methylation analysis on 23andme data, and while I have been able to figure out that I probably need to supplement methylcobalamin and methylfolate, I'm not sure if there's something else I should do. I thought I'd see if there are any other indications and perhaps what you think I should expect with these supplements I am about to start taking. Here are my mutations: Homozygous (+/+) BDR Bsm MAO-A R297R CBS A360A Heterozygous (+/-) MTHFR A1298C COMT V158M COMT H62H MTR A2756G MTRR A66G BHMT-02 BHMT-04 BHMT-08 TIA for any help, and feel free to inbox me privately if you prefer.