The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Need help analyzing 23andme results

Discussion in 'Genetic Testing and SNPs' started by uriraha8, Jun 29, 2014.

  1. uriraha8



    I have finally done the 23andme test.
    This quite surprised me cause i was sure i had some mthfr issues but i don't.
    I suffer from chronic fatigue and depression which antidepressants do nothing for it.
    I found out i have some mtr/mtrr issues which as i read this mutation needs lots of methyl B12 which i already taking 1 mg daily.
    Should i add methyl folate for it? although i don't have any mthfr mutation? Cause i feel a bit anxious when taking the methyl B12 alone.
    I also have comt mutations should it be a problem? I understand people with comt mutations can't tolerate methyl groups very well.
    Is there anything i can do with the VDR/Taq mutation? i have vitamin d deficiency but i can't tolerate high doses of vitamin d (it cause me migraine) i can only tolerate 1000IU daily.
    Should i continue with the methyl B12 and methyl folate? or exchange it to hydroxy B12 base on my results.

    Any help will do for me i really need it


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  2. Valentijn

    Valentijn Senior Member

    @uriraha - It really doesn't look like there's much of any problem showing up there. If you want to look up more MTHFR and MTRR results, I've got lists at and

    Additionally, I've got a small downloadable program at which pulls out your very rare results. Results starting with "i" are often known to be pathogenic, and homozygous results can be especially interesting as well.

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