Since last summer, I have on occasion tried taking manganese (not magnesium) - and was surprised with the results. I first took it last summer because I have very loose ligaments (noted by several healthcare practitioners), and read that manganese is needed for ligament health. I got WIRED, by the next day. A dramatic different in energy (I do not have ME/CFS, but do often have moderately low energy, along with POTS and other odd things). This wiredness was not the "tired but wired" thing people talk about, I had that years ago, and know what that feels like. Nope, this was straight up "give me all your chores I'll do them for you" wired. I had to take benadryl to sleep at night during these wired days. Not making the connection last summer, I had continued the manganese for about a week. I spent most of that week last summer trying to figure out if some change in diet had caused the wiredness (long term candida sufferer, I tend to blame diet too quickly for feeling bad). After I stopped the manganese, the wiredness took days to dissipate. Since then, every few months I've tried it again. Usually the same results. Why only "usually" - well, the one thing that might prevent the wiredness from happening from the manganese is if I eat sulfited foods in excess (dried apricots, in my case). I just noticed that this week. On the Doctor's Data website there's this page: http://www.doctorsdata.com/methylation.pdf Can anyone give me a dummies summary - help? I haven't been able to get genetic testing done yet. The Doctor's Data document has only two mentions of "manganese": The first is that SUOX requires manganese, B12, molybdenum, and boron. In the past, I've tried B12 and/or the mineral called molybdenum, and never got energy from them. (and the B12 was Freddd's recommended Enzymatic Therapy brand, still no change in energy). It says that SUOX is taxed by sulfites, and that sulfites lower manganese levels, BUT the symptoms it lists for sulfite sensitivity do not fit me: reflux, for example, (I never get reflux). All the times over the years that I have eaten the apricots, I never got any change in energy, until this week when they seemed to prevent the energy boost that manganese may have otherwise given. But the document also says people with inhibited SUOX have reactions to perfumes - I very much have this problem, and have for years. I carefully avoid being around perfumes. Over the years, I only indulged in the dried apricots about once a month, and those are the only food sources of sulfites for me, so I don't think I can blame sulfites for my perfume allergies, which are constant. So now I have no idea what to think about SUOX. The other place in the document that talks about manganese is in connection to BHMT. It mentions "increased gastrointestinal symptoms" from BHMT problems. What gastrointestinal symptoms do they mean? I have one hair test but don't think it isn't valid - it fits the Cutler description for mercury problems which derange mineral output into hair. I'll pursue chelation in the future. As for methylation in general, methyl donors do not make me wired when I have tried them as single supplements. And MB12 done via Freddd's protocol did not change my energy, and neither did Methylfolate. Manganese, you have me stumped.