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NAG helps noticeably but why?

Discussion in 'General Treatment' started by Hindi1989, May 23, 2018.

  1. Hindi1989

    Hindi1989

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    Hi guys,

    After trying tons of supplements I have finally come across something that actually helps - not significantly but noticable enough. It has reduced my brain fog 15-20% and given me 10-15 % boast in energy. It doesn't sound a lot but anything is welcome. So, why is NAG helping me and the other supplements which are too many to list unhelpful?

    I have noticed that I urinate more often than normal on NAG which is little annoying but I hope it doesn't point to something serious. I also notice it doesn't work if I continue to use it unless I give it a few days or week break. Anyone else have similar experience?

    Finally can you recommend some supplements which might amplify the effects of NAG due to their similar anti inflammatory nature. I personally believe most of my symptoms are inflammatory in nature so If I can address that I might come across significant improvements. Thanks to @Hip for suggesting NAG
     
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  2. Hip

    Hip Senior Member

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    How long would you say it took to produce those benefits? Was it within hours of taking NAG, or did it take days or weeks?
     
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  3. Ema

    Ema Senior Member

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    NAG is immunomodulatory, according to this study.

     
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  4. Hindi1989

    Hindi1989

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    Usually within hours or day and If I don't take it for a day I can see the losses immediately. Though the effects are not always consistent in terms effectiveness. When I take 1500mg on an empty stomach i notice the effects more, and while taking it on a full stomach i notice less or nothing at all sometimes. I also notice less benefits if I take less than 1500mg. I'm thinking of increase the dosage to 2+ but I'm not sure of the long term side effects especially since reading somewhere about risks of diabetes.
     
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  5. Hip

    Hip Senior Member

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    Sounds like it could be the anti-inflammatory effect of NAG that is helping you, or the fact that NAG reduces the Th17 immune response. Maybe other supplements that reduce brain inflammation might help, such as turmeric 1000 mg twice daily (not the same as curcumin).
     
  6. Gingergrrl

    Gingergrrl Senior Member

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    I don't know a lot about this supplement (even though I took it as part of a "GI Repair Powder" from a naturopath in early 2014). I was just discussing it with @mariovitali who might have some ideas about it. Unless there is more than one supplement called "NAG" (but I don't think so)?
     
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  7. mariovitali

    mariovitali Senior Member

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    NAG usefulness is twofold : It helps with T Cell activation but also helps with the Unfolded Protein response that takes place (Hypothesis). I notified Researchers about this hypothesis as early as 2015.

    Here are two excerpts from the now infamous Research document i circulated starting from October 2010 :

    Screen Shot 2018-05-24 at 05.11.23.png Screen Shot 2018-05-24 at 05.10.07.png

    The point which i am trying to make for some time now (3 years) is that we need a personalised regimen that creates the necessary environment for recovery.All it takes is for Researchers to give this personalised regimen a try.

    @Hindi1989

    I Hypothesise that you may have issues to Protein Folding / Unfolded Protein response Genes and this is why NAG helps you. But to get the most benefit you should also look at other Pathways (which are being discussed in the document i mentioned).

    Turmeric that @Hip suggests may or may not help you (and actually bring a negative result) according to my research as it may impair the function of certain CYPs in the Liver
     
    Last edited: May 24, 2018
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  8. Hindi1989

    Hindi1989

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  9. mariovitali

    mariovitali Senior Member

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    I assume that by "they" you mean the authors of the Research document? I was the one who wrote this and there are several supplements being mentioned however this document is not circulated to non-researchers because i wouldn't want people starting taking supplements in a non-informed way. Apart from this, the hypothesis is that these supplements should be taken according to each individual's DNA.

    Regarding NAG : You should definitely check if you are diabetic /pre-diabetic. Have you ever tested hba1c? Have you ever had a Glucose Intolerance Test? It is better to discuss your concerns with a Doctor.

    The UPR (Unfolded Protein Response) and ER (Endoplasmic Reticulum) Stress are two very large subjects and their importance on many types of disease are now beginning to be understood.

    Here is a nice video i found, i hope you find it useful :


     
  10. Diwi9

    Diwi9 Administrator

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    @Hindi1989 - Consider having your arginine vasopressin (also known as "anti-diuretic hormone") tested through a blood test. It may be low, which is not uncommon for people with ME/CFS, causing the need to urinate frequently. It can be treated with desmopressin and an increased intake of salt and fluids.
     
  11. gumman123

    gumman123

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    We make glucosamine through the hexosamine pathway (google image it). 2-3% of the glucose we use each day goes through the pathway which makes NAG, sialic acid, and possibly other amino sugars. Amino sugars are also called the 8 essential sugars. Google them for websites on it. We make them all from glucose. There seems to be an overlap between the 8 essential sugars, and glycos amino glycans. Of them all glucosamine seems to be the most important. Chitin is what animal shells are made of, and it is repeating units of NAG. Prawn shells, crab shells, lobster shells, snail shells, cockraoch shells etc. NAG is the second most abundant poly saccharide in nature after cellulose in grass. Type in chitin on youtube to see how chitosan- which is repeating units of glucosamine, and NAG, and glucosamine supplements are made from it.

    Prawns shells are 28% chitin
    crab shells 68%
    lobster shells 80%
    cuttlefish 25%

    the entire hexosamine pathway is in their shells so eating them gives NAG, and all the enzymes/intermediates in the pathway.
    I blended 100g of prawns whole today, and drank them, and ate some cuttlefish from the supermarket yesterday, and have ordered 1kg of cuttlefish on ebay, and will eat 20g or so a day. Cuttlefish also has calcium, and is good for the teeth to eat. I might have a problem in the hexosamine pathway at the point of GFPT1 so will be taking a glucosamine supplement or eating one of those foods everyday for the rest of my life.
    Will be trying lobster shells soon too.

    Type in glycomics on youtube for info on glyco nutrients. Over 50% of all proteins are glycoproteins. Glyco nutrients are an overlooked nutrient. Some compounding chemists or companies sell blends of herbs that contain all 8 essential sugars.

    Egg shell membrane also contains all of them plus collagen, and other important proteins. I eat a few a day. Crack some eggs into a cup, then grab the shell, and membrane, and peel out the membrane or just eat the whole shell which provides calcium too.

    Another source of glyconutrients is bone broth. Buy bones from supermarket/butchers then put them in slow cooker in water for 24-48 hours, and all the connective tissue dissolves off. It is possible to eat some of it off raw but some is too stuck to the bones to eat raw so has to be dissolved off or maybe put in the oven under high heat which I will try soon.

    Other sources of glucosamine per websites on it for dogs- chicken feet, pigs ears, green lipped mussels (they sell them in cans in supermarkets in australia which is convenient), beef trachea.

    If NAG helps one of those foods might help even more.
     

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