Here's a
recent thread about NAD+ with discussion.
I think NAD+ has huge potential - for CFS patients, older individuals, and people with chronic diseases. It has a big role in inflammation and energy.
In researching NAD+, I saved a lot of links and sent them to my parents and my doctor so they can learn about it. I posted it in the thread linked above. I'll post it here too.
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Thread on Phoenix Rising
(where I first learned about IV NAD+. Pretty short thread.)
http://forums.phoenixrising.me/inde...ical-mitochondrial-genetic-repair-poll.57797/
--The full NAD+ infusion protocol is 7-12 days of 1500mg 8 hour infusions everyday. Each infusion is $1,000-$1,500. This is said to replenish deficient levels, and nasal supplementation can then be continued as maintenance.
--South African doctor came up with an "Energy Value" based on pyruvate and lactate labs to determine your NAD+ levels and your NAD Energy Defeciency (NED) sickness. If your "Energy Value" below 100 indicate a need for therapeutic NAD+.
http://www.lunaliving.org/pdf/nad_therapy_e-book.pdf
--One user on PR (Learner1) says that he takes NAD+ via IV but at smaller doses. Says it gives him energy for a day or two.
--He found a sublingal source of real NAD+, which enabled him to sky for 5 hours.
http://liasresearch.com/
http://liasresearch.com/lias-otc.html
--Intranasal NAD+ is available but supposedly sticky and unpleasant.
Podcast about IV NAD+
Good background and primer on it - much better than next link. Interviews patient who cured his CFS, Ph.D who researches NAD+, and MD who runs NAD Infusion center. Can listen to audio or read trasncript. Worth reading whole thing. Skim the comments too.
Audio:
https://bengreenfieldfitness.com/podcast/anti-aging-podcasts/what-is-nad/
Transcript:
https://bengreenfieldfitness.com/transcripts/transcript-what-is-nad/
--"A lot of the enthusiasm about resveratrol is the fact that it was theoretically driving sirtuin activity. What’s interesting is that sirtuins are like a factory, like any enzyme, they won’t function unless they have, if you like, the raw material for that factory to work on, and NAD is that raw material."
--NAD works at the epigentic level.
--"Another OTC supplement to raise NAD+ is nicotinamide. It can be recycled through to NAD. The negative thing with having too much nicotinamide, as opposed to the other types of NAD precursor [NR and NMN] that I’ve mentioned, is that nicotinamide is a byproduct. Now, you’ve heard we’ve talked about CD38, we’ve talked about sirtuins, and talked about the PARPS. So CD38, the immune modulators, the Sirts, the epigenetic modulators, and PARPS, the DNA repair enzymes. Now all of those three, when they use NAD, they will actually generate nicotinamide as a byproduct. As the levels start to go up in the cell, the nicotinamide starts to inhibit those enzymes, the CD38s, the sirtuins, the PARPs. And so too much nicotinamide, unfortunately, can stop the very reactions that you want to have acting. So, we would probably suggest that getting it from some of the other sources, the nicotinamide riboside, NMN, or nicotinic acid would be better."
--"You can find nicotinamide riboside as a supplement, and nicotinamide riboside, like NMN, will be converted through to NAD. In fact, nicotinamide riboside is converted first to NMN, and then through to NAD.... But taking the other two, the NR, the nicotinamide riboside, or the NMN, neither of those will produce nicotinamide until it goes through NAD."
--
Q: "How big of a difference is there between intravenous NAD and taking NAD as a supplemnt"
A: "We suffer from lack of NAD because we’re using it up and not replenished in proper levels, and it’s the cause of underlying aging, and other disease processes. So I think that you have to sort of flood the body with NAD to start off with, but then you can supplement, and that’s why we use intravenous. Then you can supplement NAD with a pure source of NAD that we give intranasally that I think is a very good method of continuing to substitute to boost your NAD levels."
--NAD+ levels drop 40% as you age. Another study showed every 20 years, you experience a 50% drop in NAD+. Another study tested people under 45 and over 45 for their NAD levels and they found that 300% increase in the average between the pre- 45 and post-45. Also, another study shows that it seems to exponentially increase after age 60 the loss of NAD.
--Can measure NAD levels in blood, but hard to get the lab to do it right. Rapidly degrades after blood draw.
--"Even the MTHFR gene has improved with NAD+."
--From the comments on the audio page link: “In the suprachiasmatic nucleus, biological rhythms are maintained by a central clock of around 20,000 pacemaker neurons.¹ These neurons can degenerate with age and oxidative stress. NAMPT/NAD drives the circadian clock feedback cycle through SIRT1 and Clock:BMAL1². As the NAD levels oscillate over the circadian cycle the activity of SIRT1 oscillates linking the metabolic state of the cell through an epigenetic mechanism to the circadian clock.¹”
Short Scientific Explanation & Background:
http://www.life-enhancement.com/magazine/article/2947-its-a-nad-nad-nad-nad-world
http://www.life-enhancement.com/magazine/article/2986-its-a-nad-nad-nad-nad-world-part-ii
http://www.life-enhancement.com/magazine/article/676-can-nad-help-extend-human-lifespan
NAD+ in Press:
https://blogs.scientificamerican.com/guest-blog/beyond-resveratrol-the-anti-aging-nad-fad/
http://www.dailymail.co.uk/health/article-4370092/Is-pink-pill-elixir-youth.html
https://www.vice.com/en_us/article/bn3vmq/nad-plus-brain-reboot-infusion-injection
Important Papers on NAD+ and aging:
Declining NAD+ Induces a Pseudohypoxic State [my emphsis]
Disrupting Nuclear-Mitochondrial Communication during Aging, which we show is reversable (Pseudohypoxic state has been used to describe the pathology of CFS/ME, like a form of sepsis)
https://hms.harvard.edu/news/genetics/new-reversible-cause-aging-12-19-13
Full paper & abstract:
http://www.cell.com/abstract/S0092-8674(13)01521-3
NAD Key in Autoimmune Disease: delays disease onset and reverses disease progression
https://hms.harvard.edu/news/new-discovery-regulating-autoimmune-diseases
Full paper and abstract:
https://www.nature.com/articles/ncomms6101
"Here we show that administration of NAD+ protects against EAE and reverses disease progression by regulating CD4+ T-cell differentiation and apoptosis through a novel signalling pathway and by promoting myelin and axonal regeneration."
NAD+ Is a Food Component That Promotes Exit from Dauer Diapause in Caenorhabditis elegans
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167208
Note: Naviaux called CFS/ME a "dauer" state and said our metabolimics and disease most closely resembled the dauer state in C. elegans. He's used this same model and dauer state for our disease.
Discussion:
http://forums.phoenixrising.me/inde...that-promotes-exit-from-dauer-diapause.57363/
Other NAD+ Papers and Research:
NAD+ and NADH in cellular functions and cell death
NAD+ and NADH in brain functions, brain diseases, and brain aging
NAD+/NADH and NADP+/NADPH in cell ular functions and cell death: regulation and biological consequences.
https://static1.squarespace.com/static/53580835e4b0c3ad7382ddb6/t/5384b2b3e4b0b1911ba23a44/1401205427488/J) NAD+.pdf
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment.
https://www.ncbi.nlm.nih.gov/pubmed/25678560
Prevention of Traumatic Brain Injury-Induced Neuron Death by Intranasal Delivery of Nicotinamide Adenine Dinucleotide
http://online.liebertpub.com/doi/pdf/10.1089/neu.2011.2228
NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NRNeed to use ATP to convert NR to NAD+
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30670-8
Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice. Cell Metabolism.
https://www.decodedscience.org/nmn-nicotinamide-mononucleotide-lowers-blood-glucose-in-mice/3616
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of circadian rhythem, metabolism, and aging.
http://europepmc.org/abstract/med/19897060
Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis
http://molpharm.aspetjournals.org/content/molpharm/early/2011/09/14/mol.111.073916.full.pdf
Differences Between NAD+ Metabolites Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR):
Niagen offers NR and that's what has been done in human studies showing increase in NAD+. It's also a product that came out first. NMN appears to be better, but there's only a few products of it out there and there isn't a human study showing its effectiveness. TokyoU & WashU are starting a human trial in 2018 to be done in 2020. Links below is from a site that sells NMN supplements, but has some good graphs and data from the research. The site may have more pages that show more info too.
http://alivebynature.com/nmn-or-nr-whats-the-best-nad-booster-3/
http://alivebynature.com/about-niagen/
http://alivebynature.com/does-nr-break-down-to-nam-before-nad/
http://alivebynature.com/in-nmn-the-best-way-to-improve-your-healthspan/
http://alivebynature.com/nicotinamide-riboside-optimum-dosage/
Interesting Evidence:
Total and complete normalization of QEEG scan by NAD+. Look at before and after pictures. Same type of scan I had for neurobiofeedback (they even mention Dr. Jay Gunkelman who read my scan). A lot more effective than neurobiofeedback ever was.
https://emerald-neuro-recover.com/brain-scan
"NeuroRecover ™ has been shown on SPECT brain scans performed at the Dr. Daniel Amen Clinics, in images taken before and after treatment, to promptly bring about significant improvement in function in the drug-damaged brain." I'm emailing and waiting to hear if they have pictures/evidence/a case study of this claim.
http://chwbonline.com/medical-services/neurorecover/
Compounding Pharmacies that Sell It
https://supplementpolice.com/nad/#comment-21937
Archway Apothecary in Louisiana (also do a nasal spray & oral NAD+)
Anazoa Phamacy in Tampa
https://www.alternet.org/drugs/does...iracle-cure-addiction-and-disease-really-work
Hayden Pharmacy
https://www.reddit.com/r/StackAdvice/comments/5pq00p/where_to_get_iv_nad_solution/
College Pharmacy
Comment saying a "full protocol" costs $1,000 from College Pharmacy and having a doctor friend prescribe it.
NAD+ Infusion Clinics Pages:
Springfield Wellness started/brought NAD in/to the US. Longest running clinc providing NAD and have developed the protocols.
http://www.springfieldwellnesscenter.com/
https://custommedicine.com.au/nad-nicotinamide-adenine-dinucleotide/
https://innovativemedicine.com/closer-look-nad-brain-restoration-therapy/
https://www.ivforlife.com/nad-fountain-youth-2/
http://chwbonline.com/medical-services/neurorecover/
Conference on NAD+ Therapy:
https://www.nadsummit2018.com/
http://www.brplusnadsummit.com/about-our-summit/
(From the podcast interview)
http://www.brplusnadsummit.com/ross-grant-phd/
(From next NAD+ email and blog, Anti-agingFirewall.com)
http://www.brplusnadsummit.com/james-paul-watson-m-d/
Videos / Testimonials
Parkinsons and NAD+
Alzheimer's and NAD+
NADH (not NAD+) and Parkinsons (There have been previous, older studies of NADH improving Parkinsons. This video is pretty extraordinary.)
