Hi Guys, i'm new member from Europe. This is my history...(sorry for bad english but use a translate). I try to summarize my situation by not always opening new posts. I was born as a hyperactive child in fact I was never standing still. The academic performance has never been excellent in fact I had great difficulty in metamatic. Around the age of 14 I begin to feel a strong discomfort in being observed while I play football especially when there was the official match. In training where there was less pressure I was calmer. During the game I no longer understood anything, physical and verbally blocked. I avoided eye contact with others. I brought all these inconveniences including fear, paranoia, anticipatory anxiety even in everyday life ... social anxiety and doing things in front of others for me was impossible ... even the slightest things. Big difficulty in supporting the looks of people both male and female. Let's say we can summarize with "paranoid schizophrenia" even if I have never been officially diagnosed ... surely I had or rather say I still have a non-high GABA ... with symptoms of the autistic spectrum. (verbal difficulty linguage , speak...etc) I begin to take SSRIs in even high enough doses for months without apparent success. I change different psychiatrists and I start other therapies based on drugs like SNRI and anti-psychotics that have led me to great side effects including a serotoninergic crisis. I also take benzodiazepines without positive results. I do this for several years until one day I try intermittent fasting. Within a few days I feel an energy never felt before. Mental lucidity, high libido, physical prowess and energy without apparently changing my diet. The body temperature is higher and the metabolism seems to go very fast. In 2014, unfortunately I had not learned about the methylation cycle and all that is connected (BH4, COMT, DAO, and the various mutations of SNP) and I had linked the benefits only to the "magic" of fasting. (now reading well I know that the MAT1 gene has correlations with fasting and growth hormone but the most experienced will deny me or give me reason if it is related). Practically after 3 months I start to feel very bad. The metabolism seems blocked and mentally they are off. No emotion, no empathy, sensitivity to light and very high noise. I can not support the looks of people. I eat out of boredom and certainly because I did not have high dopamine. I lose a lot of muscle mass and I start to gain weight. Physical activity gives no benefit and the diet does not even. My parents forced me to resume medication without obviously success but only negative effects .... the situation worsened. In 2016 I start testing nootropics with some little satisfaction but the situation is not resolved. My exams of the sague (in Italy I do not have specific exams like in America where you are more up to date) are however regular including hormones (only testosterone little low). Only in this last month I come to know the cycle of methylation and all that is related. Having no specialist in Italy that follows this thing I decide to start alone taking the Methylfolato Jarrow (I hope you can make the name) 400 mcg alone in the morning. I feel after 2-3 days immediately a slight benefit ... almost the same ones that I had felt the first time with the fast ... a very special feeling and inside me I said "hell this could be the right way". Nowadays it is 12 days and I have increased the methylfolate to 800mcg by combining the B12 in methylated form and about 1gr of Vit. C per day. The diet is a mixed variety of Paleo style but with Carbohydrates it makes fruits, potatoes, rice and gluten-free foods. I think that eliminating them completely makes little sense especially for someone like me who has always trained. My problem now is not to make mistakes and go back to the starting point. I have no tests in Italy that can diagnose with SAFETY what mutation I have and all the SNPs related to MTHFR. I have not analyzed my Homocysteine levels yet but I can do this on Monday. They will probably be staggered due to the intake of Methylfolate and B12. Based on what I wrote where could the mutations be? I bought Dr. Lynch's Dirty Gene but I'm in trouble with English and I use a translator. If there is a professional medical figure to whom I can apply, you can also write to me in private. The photos below indicate the state in which I was reduced in the years after the fast. I had lost facial expressiveness totally. Now I'm 10kg more and I'm pretty well physically. Posted my recent Lab Work for Homocysteine, Folic Acid and B12 (I tested this from 12 days when started with Methylfolate 800-1000 mcg and 1000 mcg of MethylB12.