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My Situation: Please Help

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Methyl90, Oct 23, 2018.

  1. Methyl90

    Methyl90

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    Hi Guys, i'm new member from Europe. This is my history...(sorry for bad english but use a translate).

    I try to summarize my situation by not always opening new posts.

    I was born as a hyperactive child in fact I was never standing still.

    The academic performance has never been excellent in fact I had great difficulty in metamatic.

    Around the age of 14 I begin to feel a strong discomfort in being observed while I play football especially when there was the official match. In training where there was less pressure I was calmer.

    During the game I no longer understood anything, physical and verbally blocked. I avoided eye contact with others.

    I brought all these inconveniences including fear, paranoia, anticipatory anxiety even in everyday life ... social anxiety and doing things in front of others for me was impossible ... even the slightest things. Big difficulty in supporting the looks of people both male and female.

    Let's say we can summarize with "paranoid schizophrenia" even if I have never been officially diagnosed ... surely I had or rather say I still have a non-high GABA ... with symptoms of the autistic spectrum. (verbal difficulty linguage , speak...etc)

    I begin to take SSRIs in even high enough doses for months without apparent success.

    I change different psychiatrists and I start other therapies based on drugs like SNRI and anti-psychotics that have led me to great side effects including a serotoninergic crisis. I also take benzodiazepines without positive results.

    I do this for several years until one day I try intermittent fasting.

    Within a few days I feel an energy never felt before.
    Mental lucidity, high libido, physical prowess and energy without apparently changing my diet. The body temperature is higher and the metabolism seems to go very fast. In 2014, unfortunately I had not learned about the methylation cycle and all that is connected (BH4, COMT, DAO, and the various mutations of SNP) and I had linked the benefits only to the "magic" of fasting. (now reading well I know that the MAT1 gene has correlations with fasting and growth hormone but the most experienced will deny me or give me reason if it is related).

    Practically after 3 months I start to feel very bad. The metabolism seems blocked and mentally they are off. No emotion, no empathy, sensitivity to light and very high noise. I can not support the looks of people. I eat out of boredom and certainly because I did not have high dopamine. I lose a lot of muscle mass and I start to gain weight. Physical activity gives no benefit and the diet does not even. My parents forced me to resume medication without obviously success but only negative effects .... the situation worsened.

    In 2016 I start testing nootropics with some little satisfaction but the situation is not resolved. My exams of the sague (in Italy I do not have specific exams like in America where you are more up to date) are however regular including hormones (only testosterone little low).

    Only in this last month I come to know the cycle of methylation and all that is related. Having no specialist in Italy that follows this thing I decide to start alone taking the Methylfolato Jarrow (I hope you can make the name) 400 mcg alone in the morning. I feel after 2-3 days immediately a slight benefit ... almost the same ones that I had felt the first time with the fast ... a very special feeling and inside me I said "hell this could be the right way". Nowadays it is 12 days and I have increased the methylfolate to 800mcg by combining the B12 in methylated form and about 1gr of Vit. C per day. The diet is a mixed variety of Paleo style but with Carbohydrates it makes fruits, potatoes, rice and gluten-free foods. I think that eliminating them completely makes little sense especially for someone like me who has always trained.

    My problem now is not to make mistakes and go back to the starting point. I have no tests in Italy that can diagnose with SAFETY what mutation I have and all the SNPs related to MTHFR.

    I have not analyzed my Homocysteine levels yet but I can do this on Monday. They will probably be staggered due to the intake of Methylfolate and B12.

    Based on what I wrote where could the mutations be? I bought Dr. Lynch's Dirty Gene but I'm in trouble with English and I use a translator.

    If there is a professional medical figure to whom I can apply, you can also write to me in private. The photos below indicate the state in which I was reduced in the years after the fast. I had lost facial expressiveness totally. Now I'm 10kg more and I'm pretty well physically.

    Posted my recent Lab Work for Homocysteine, Folic Acid and B12 (I tested this from 12 days when started with Methylfolate 800-1000 mcg and 1000 mcg of MethylB12.
     

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  2. Sushi

    Sushi Moderation Resource Albuquerque

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    bump
     
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  3. Eastman

    Eastman Senior Member

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    @Methyl90

    My sympathies to you. Psychiatric problems are terribly difficult to resolve, and the conventional drugs used to treat them seldom work for long and often have serious side effects, as you have noted.

    Apart from folate and B12, have you considered other nutrient supplementation? Many nutritional deficiencies are suspected to cause psychiatric symptoms.

    The B vitamins, especially B1, B2 and B3, can have both psychiatric and metabolic benefits, especially when a deficiency shows up in blood tests, but sometimes even when it does not.

    B1 in particular has been found helpful by many members on Phoenix Rising, and may even help the body utilise the folate and B12 that you are taking.
     
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  4. Learner1

    Learner1 Forum Support Assistant

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    So can B6.
     
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  5. Methyl90

    Methyl90

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    if I am not mistaken, vitamin B3 removes methyl groups and therefore causes a slowing of the methylation cycle. It's correct ? but it would help with the symptoms of schizophrenia. As for B1, B2, B6, what are the appropriate starting dosages? do they exist in methylation form? thank you all for the answers .... have a support and someone who understands you is beautiful.
     
  6. Methyl90

    Methyl90

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    I had a bad feeling today after the race as if the adrenaline was not coming down and the beats remained very high, mental confusion, agitation, restlessness, panic, warmth to the face and ears.

    This morning I added the B6 25mg but I understand that without being followed by a doctor the situation becomes very difficult.

    How can I find a qualified doctor without spending high numbers? anyone who is willing can write to me in private. I hope this request is not against the regulation of the Forum.

    Thank you
     
  7. Hufsamor

    Hufsamor Senior Member

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    Ah, yes, here it is:)
    Hope you gets some answers :heart:
     
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  8. Eastman

    Eastman Senior Member

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    @Methyl90

    Yes, vitamin B3 removes methyl groups and slows methylation. Considering your latest symptoms, though, that might not be a bad idea. Or you could cut back or stop your methylation treatment for a while. In my own experience, overstimulation symptoms from methylation treatment persisted for weeks after I stopped it, and my symptoms were milder, mainly insomnia.

    For starting dosages for the B vitamins, you could consider the fact that many B complex supplements provide most of the main vitamins at 25 mg. But since some members here report B complexes as giving problems (e.g. see here), you might want to start lower than that, then titrate up.

    B vitamins generally don't come in methylated forms, but some may come in active forms. For example, B6 is usually sold as pyridoxine but in some supplements, it comes as pyridoxal 5'-phosphate, the active form that is actually used in the body and that pyridoxine gets converted to after absorption. There is no consensus on whether active forms are necessarily better, but some members report better results from them.
     
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  9. Methyl90

    Methyl90

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    Thanks! This Morning i read One document Yasko and here wrote that the hot ears are a symptom of high histamine so probably during the intense uphill exercise you got up too much? Something like this has not happened to me for some time and I do not understand if it's a bad or positive thing that methylation is adapting. Considering that I have symptoms of schizophrenia I should be now a sucrethalate with a low histamine ... but probably the theory does not always agree with the practice. This morning I did not take either the methylfolate or the vitamin b12 and b6 and I am quite well without any negative symptoms. I think that as Dr. Lynch says not to take them every day is a good idea ... even if I do not really know if the cause of yesterday is the fault of the supplements. What do you think about it ?
     
  10. Methyl90

    Methyl90

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    After about 3 hours from the meal (rice, potatoes, mushrooms, rabbit meat) I start to accuse dry eyes and a slight drop in prefrontal dopamine definitely. I do not think this is a matter of blood sugar or insulin because they are regular.
     
  11. Eastman

    Eastman Senior Member

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    @Methyl90

    I don't have insight into your histamine problem, and I'd think you probably need to confirm it anyway.

    The relief of some of your symptoms when you stopped methylfolate and B12 does suggest that they were creating problems for you.

    Since you mentioned Ben Lynch, he does have an article listing a series of things you can do to prevent methylation treatment side effects, in case you haven't seen it.

    I'm not sure how this relates to you but B12 deficiency has been linked to dry eyes and eye pain.

    Management of Ocular Neuropathic Pain With Vitamin B12 Supplements: A Case Report

    Vitamin B12 deficiency evaluation and treatment in severe dry eye disease with neuropathic ocular pain
     
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  12. Methyl90

    Methyl90

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    @Eastman

    In Italy I can not verify my level of histamine in the blood but I'm looking for a solution.

    However, concerning ocular dryness occurs mainly after meals, mainly those with starch, in fact, at breakfast, consuming cocoa, honey, milk, eggs I have no negative effect. I wrote mainly because I have sporadic memories that happened to me even when I was fasting.

    It must be said that in the morning I take the B12 in methylated form so this could help. I can try to divide the dose of 1000mcg between breakfast and lunch and the same with 1000mcg of methylfolate. Could help ? In the evening I am now very tired and I go to bed early.

    My cortisol is regular.

    Thanks for the link I had seen him where he recommends the use of Niacin 50mg. Do you think that niacinamide has the same effect? I have this at home but they are 500mg capsules from Now Foods.
     
  13. Moof

    Moof Senior Member

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    @Methyl90 – I'm sorry you're having such a difficult time. I really hope you manage to improve your health and your situation.

    Have you ever been assessed for autism spectrum disorder? Your history of hyperactivity, maths difficulties and social anxiety sounds very like mine, and I have Asperger's syndrome.
     
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  14. Methyl90

    Methyl90

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    @Moof in fact, not supporting the gaze could also be related to symptoms of the autism spectrum ... but I honestly do not connect this to my case because as soon as I take vitamin B6 I have none of this. (It is an important cofactor for homocysteine). I know it sounds strange but that's how it is. The high homocysteine is also due to a low activity of NMDA receptors with consequent imbalance between glutamate and GABA. Two neurotransmitters implicated in schizophrenia. Your thoughts on my reasoning based on the documents I found on the web? thank you :)
     

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  15. Eastman

    Eastman Senior Member

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    That would be an interesting trial. Please let me know the result if you do.

    Is this only after methylation treatment? If so, it's possible that it's just the result of increased melatonin but it could also be something more insidious. There are discussions around Phoenix Rising that suggest that methylation treatment increases the need for B1.

    Niacinamide is actually the form that directly absorbs methyl groups. Nicotinic acid, the form that many people mean when they refer to niacin, has first to be converted to niacinamide in a roundabout route. Anecdotal reports on Phoenix Rising and elsewhere do suggest to me that it effective though, possibly through an alternate pathway that I am not aware of.
     
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  16. Methyl90

    Methyl90

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    I wanted to update with a little 'details as they are continuing my days ... maybe someone sees or wants to help me. I always point out that I'm using Google Translate and this is a copy paste of the conversation I'm privately having with a really nice user (Learner1, I hope it does not bother you if I do your name).

    Since I was a child I have always had a great difficulty in coordinating thought, language, eye movement and movement when I find myself in difficulty or in situations that I have not calculated and new.

    It is not automatic but I have to think and calculate in advance.

    There is no naturalness in things and emotions.

    I found that a deficiency or defects in the gene / enzyme MTHFR lead to states of "catonia" that can occur in different ways and is mainly related to schizophrenia (in my case I would say paranoid ... I still have songs that start automatically in the head and the visions of things that are not there, but not in a constant way, are sporadic).

    To make you understand the degree of "disability" I can not speak while I make a video with the smartphone because it shows precisely my inability to coordinate language, eyes and thought. I would have a big fear to face an interview with a person who talks to me and a camera pointed at me. It is as if the brain and body are in a state of "protection" and give up the situation.

    I think that during my 28 years I have had both low and high methylation ... I say this because I'm starting to understand something.

    As for your questions I can tell you that my thyroid is in a "Hyper" state when TSH is very low. The temperature, however, does not move much from the 36.5 ° constants even after meals when it should go up for thermogenesis. Sometimes I have hot ears, this happens in recent weeks.

    Urino very at night without apparent cause. My uric acid from the tests is regular so I think the urea cycle is ok.

    Anxiety is above all anticipatory and on new occasions, where there are commitments.

    The inability to pay attention is less since I started methylfolate and vitamin B12 but I've always had it.

    I recognize the faces without problems and when I'm "good" I can speak quite well.

    I do not dream much, lately a little more and are quite clear.

    Irritability seems to me more pronounced when I do not masturbate, I think for the increase of testosterone, the lowering of prolactin and the increase of dopaminergic receptors.

    I have no marked and relevant pain, only quite "noisy" joints.

    Insomnia linked to urine at night but anyway I find it hard to really relax.

    I'm struggling less than in the last few years, but on a scale of 1 to 10 I think I'm 6-7, especially after a workout I'm quite "spoiled"


    My "diet" is mainly based on: bitter cocoa / about 50-70gr per day, eggs 2-3 a day, lean meat of chicken and turkey and occasionally red meat of beef or horse. skimmed milk and some cheese. Burro.Patate. Use cronometer to monitor above all the micronutrient vitamins and minerals.

    Current integration is methylfolate, methylated b12, b6, and vitamin C.

    Usually I take it all in the morning which is the moment when I feel more and more "off" and that I need a boost to the methylation to leave.

    1000mcg B9
    1000mcg B12 sublingual
    25mg B6 (50mg last two day 6-7 nov)
    250-500mg Vit. C
    B2 last two days 6 nov and 7 12mg lunch and 12mc dinner

    I also consume many red turnips, about half a kilo a day and the usual fruit and vegetables varies.

    One coffee a day

    Where would you bring some changes? I hope next week to test at least histamine and zinc and do the MTHFR test.

    I wanted to answer you serious yesterday but I really had a bad time that continued until the following morning, that is today while I'm writing to you. Basically I had an attack of desire to eat compulsive, probably because of low dopamine but it is just a hypothesis ... I was looking for something that would satisfy me, in fact, after a week I masturbated. In the moment of great relief, but this morning I got up with a swollen face, light depression and a lack of mental clarity. The swelling is probably due to the release of prolactin to the detriment of the testosterone (which was high from the exams). I basically wake up with an expressionless face, including the eyes ... if I take a picture or I'm photographed you can see very well. Remember when I was good with the fast I had a beautiful face and expressive, as well as a little 'more skinny. If you like, I would like to show you some photos via email or whatsapp if you use it.

    My MCV just examined is 88.7fl.

    Doctors I practically turned all the psychologists and psychiatrists possible taking a lot of useless drugs including SSRI, SNRI, Antipsychotics, anxiolytics.

    Regarding the thyroid I have checked in the past few years all the values you mentioned and were always on the scale of the laboratory. I checked a few weeks ago for the sake of TSH and it remained the same.

    I have no chance of testing selenium but I eat a lot of it including selenium in my diet.

    The urine is ok, but I can not verify citrulline and ornithine. Aldosterone was a little taller years ago but probably from pre-exam anxiety. When I have to do the tests the veins disappear ... but I do not know if it is a lack of nitric oxide in the morning due to inefficient methylation or anxiety that causes vasoconstriction (but in this case not even the blood would come out).

    The same discrete applies to GABA and glutamine, I do not have a laboratory that can do it.

    Theanine worked initially but then being NMDA agonist worsened the symptoms of schizophrenia when the effect ended. Magnesium consumption about 0.5gr according to the application cronometer.

    Regarding the tests 23andme is worth the same speech that I have already given you. By residing in Italy, I can no longer send my DNA around the world ... it is absolutely forbidden. Even 23andme replied to me like that. I know I'm really limited from this point of view because I could already have a lot of answers to all this faulty brain chemistry.

    I look at the beetroots consumption because I have read TMG that is a methyl donor and lowers the homocysteine. I'm doing it wrong ? even onions I eat enough but maybe it's better that I limit the sulfur?

    I have Thiamine at home (B1) and riboflamin respectively 100mg per capsule. Are they too many to try?

    This morning I increased B6 to 50mg and took about 6-7mg of zinc methionine also to make up for last night's orgasm because maybe I'm very sensitive to the loss of nutrients that orgasm causes. Really interesting that test at $ 189 but what do you think if you try to send it to me and I send it to you with a private mail service? I do not really have a lot of money to spend, in fact I have not really considering how much I have spent among the various psychiatrists but if you gave me a hand I would be grateful indeed.

    Rereading I wrote some inaccuracies. I said that I also consume enough iodine in the diet as well as in selenium. Teanine is NMDA antagonist, not an agonist like glycine that is in fact used in treatments for schizophrenia such as serine.

    I must say that yesterday morning was really tragic but I do not know if it is only due to having had an orgasm the night before. I have read on this Forum that many people with ME / CFS report cases similar to mine. I have also read that there are supplements that can help in post-stress such as creatine and other substances. The only times I took the post-workout creatine I had a swelling mostly in the face (I know it's normal for creatine to retain fluids) and the negative symptoms came back to the surface. In fact, the metabolism of creatine is linked to the SamE is certainly if there are methylation disorders the situation is aggravated. Do you agree with me ?

    Returning to the day yesterday passing the hours I was better especially after taking 100mg of Riboflamin B2.

    This morning Wednesday 7 just turned up pretty well and I took my usual fasting things: Methylfolate, Methylcobalamine, B6 (second day at 50mg) and after lunch instead I wanted to test a very low dose of B2 about 10-12mg but not I noticed no particular mental or physical effect. This evening before dinner I will take another 10-12mg and I keep this dosage for 2-3 days and then evaluate the increase. Does this second thing make sense or do I always keep a fixed dosage? I also trained with rings this morning and after the training I did not have a post-stress crash.

    Slight feeling of dry and irritated eyes after lunch.

    I went to a store and to realize the symptoms that appear when there are new people practically while I connected the zipper that has jammed ... I went into "panic" for how to solve the problem and feel a strong heat in face. I do not know if the lack of availability of dopamine in the prefrontal part is the cause ... that runs out too well ... according to Dr. Lynch's dirty gene book I could have a fast COMT and a low MAO that would imply having little B2. This is just my theory, obviously based on the symptoms that happen to me when I am embarrassed or in the presence of new people ... or it is only mine while "little developed in neurotransmitter" ... and therefore it is only a matter of time in coming months setting up methylation I could solve all this once and for all ... and above all find a job and do things without worries of being observed and panic.

    All in all I feel more circulation, today it is really more constant especially the veins on the forehead of the head that usually are not seen so '... but I have no headache.

    Sorry for the long writing but I like to realize every day how I am, my progress, and my difficulties that are not yet understood. Surely my ability to think and to think again is not fast in the presence of strangers ... at home all in all I'm pretty well ... I still can not pay attention when others speak for example if I have 3 people talking to me in front of me it is difficult to make the "switch" with the thought and the gaze towards that person.

    I am looking for a doctor in the UK who can send me the test so that Genoa can do the analysis.
     
  17. Mary

    Mary Moderator

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  18. Methyl90

    Methyl90

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    Yesterday November 10th was a special day in the sense that afternoon I had an appointment to meet with my cousin to fix a problem with the bike I have in the garage. I took my usual integration in the morning. The afternoon passed quite well even if I struggled to pay attention to it while talking to me and solving the problem with the drill. I think the others can tell me that I can not be careful at all ... I do not know if I explain myself. In any case, I felt more sociable and helpful and a little more mentally responsive. Once I got home but I felt a bit 'exhausted both mentally and physically ... as if I had a mental exhaustion and I need to recharge myself eating ... in fact I was more inclined to binge ... this thing I remember it too when I was little before 10 years. I also noticed under the tongue a "cut" as I mentioned the other day ... practically remains partially attached to the palate.Inoltre I do not know if I told you my appearance of the face is like when I was little, too much young. Is it always a sign of MTHFR deficiency and methylation? In the meantime, I intend to try to increase the methylfolate and the B12 or just one of the two.

    Which one would you suggest to increase? I was thinking about the methylfolate going up to 1400mg also because this morning I'm still feeling a bit tired from yesterday. It could also be insufficient glutathione.
     
  19. taniaaust1

    taniaaust1 Senior Member

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  20. Eastman

    Eastman Senior Member

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    @Methyl90

    Unfortunately, your latest updates gave me no further insight into your condition.

    A trial increase in methylfolate dosage seems a good idea, as it is widely recognised as important for mental health, and, according to the following paper, is often found deficient in those with psychiatric disorders.

    Nutritional Deficiencies and Clinical Correlates in First-Episode Psychosis: A Systematic Review and Meta-analysis

    The above paper also found vitamin D to be frequently deficient in those with schizophrenia, as did the following paper.

    Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

    The following paper found vitamin D to be helpful in improving psychiatric conditions.

    Vitamin D, light and mental health

    Also, for a general review of vitamin D in brain health:

    The Role of Vitamin D in Brain Health: A Mini Literature Review

    The paper I linked to earlier lists other nutrients you might want to consider.
     

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