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My genetic results, need suggestions please

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by musicfreak, Apr 24, 2013.

  1. musicfreak


    Hi guys,

    I downloaded my raw data from 23andme and uploaded to Genetic Genie.

    I'm herterozygous for MTHFR C677T. I know I need folic acid and B12 in the methyl form.

    I'm really surprised to see I'm -/- for A1298C since I've always been told I had CFS/FM.

    I read that having MTHFR mutations can make you prone to infections and detoxing which are my issues. Do one of the mutations (C677T and A1298C) cause that more than the other as I just have a problem with C677T.

    Any suggestions on how to treat the other mutations would be greatly appreciated. There is less info about them compared to MTHFR. I know some are a concern. I will check out Dr. Yasko's website for more info.

    Here are are my results:

    Methlyation Analysis:

    Gene & Variation rsID Alleles Result
    COMT V158M rs4680 AG +/-
    COMT H62H rs4633 CT +/-
    COMT P199P rs769224 GG -/-
    VDR Bsm rs1544410 CC -/-
    VDR Taq rs731236 AA +/+
    VDR Fok-I not found n/a n/a
    MAO A R297R rs6323 GT +/-
    ACAT1-02 rs3741049 GG -/-
    MTHFR C677T rs1801133 AG +/-
    MTHFR 03 P39P rs2066470 GG -/-
    MTHFR A1298C rs1801131 TT -/-
    MTR A2756G rs1805087 AG +/-
    MTRR A66G rs1801394 GG +/+
    MTRR H595Y rs10380 CC -/-
    MTRR K350A rs162036 AA -/-
    MTRR R415T rs2287780 CC -/-
    MTRR S257T not found n/a n/a
    MTRR A664A rs1802059 GG -/-
    BHMT-01 not found n/a n/a
    BHMT-02 rs567754 CT +/-
    BHMT-04 rs617219 AC +/-
    BHMT-08 rs651852 CT +/-
    AHCY-01 rs819147 CT +/-
    AHCY-02 rs819134 AG +/-
    AHCY-19 rs819171 CT +/-
    CBS C699T rs234706 GG -/-
    CBS A360A rs1801181 GG -/-
    CBS N212N rs2298758 GG -/-
    SUOX S370S not found n/a n/a
    NOS3 D298E not found n/a n/a
    SHMT1 C1420T rs1979277 GG -/-

    Detox Profile:

    Gene & Variation rsID Alleles Result
    CYP1A1*2C A4889G rs1048943 TT -/-
    CYP1A1 m3 T3205C rs4986883 TT -/-
    CYP1A1 C2453A rs1799814 GG -/-
    CYP1A2 164A>C rs762551 AA -/-
    CYP1B1 L432V rs1056836 CG +/-
    CYP1B1 N453S rs1800440 TT -/-
    CYP1B1 R48G rs10012 CG +/-
    CYP2A6*2 1799T>A rs1801272 AA -/-
    CYP2A6*20 rs28399444 II -/-
    CYP2C9*2 C430T rs1799853 CT +/-
    CYP2C9*3 A1075C rs1057910 AA -/-
    CYP2C19*17 rs12248560 CC -/-
    CYP2D6 S486T rs1135840 CG +/-
    CYP2D6 100C>T rs1065852 AG +/-
    CYP2D6 2850C>T rs16947 GG -/-
    CYP2E1*1B 9896C>G rs2070676 CC -/-
    CYP2E1*1B 10023G>A rs55897648 GG -/-
    CYP2E1*4 4768G>A rs6413419 GG -/-
    CYP3A4*1B rs2740574 TT -/-
    CYP3A4*2 S222P rs55785340 AA -/-
    CYP3A4*3 M445T rs4986910 AA -/-
    CYP3A4*16 T185S rs12721627 GG -/-
    GSTP1 I105V rs1695 GG +/+
    GSTP1 A114V rs1138272 CC -/-
    SOD2 A16V rs4880 AG +/-
    NAT1 R187Q rs4986782 GG -/-
    NAT1 R64W rs1805158 CC -/-
    NAT2 I114T rs1801280 CC +/+
    NAT2 R197Q rs1799930 GG -/-
    NAT2 G286E rs1799931 GG -/-
    NAT2 R64Q rs1801279 GG -/-
    NAT2 K268R rs1208 GG +/+

    I've been sick 29 years, since I was 15. I figured I had CFS/FM. I suffer constant fatigue and muscle pain plus 40 other symptoms. I have hypothyroidism, adrenal exhaustion, and chronic systemic candida all these years. Recently I found out I have Lyme disease. My tests were negative according to the CDC and IGenex but I had 4 INF's and one + on lyme specific bands so I've obviously been exposed to it. It also showed up on energetic tests I did along with Babesia and Bartonella. That energetic test also revealed I have many viruses, staph, parasites, worms (not seen in the bowel so must be microscopic). I also have high mold toxins in my body. There is a certain gene I need to test for that. I don't think it's in 23andme results. I have to detox the mold toxins first if I want to heal from Lyme. And I have mercury poisoning as well as aluminum, arsenic, tin and titanium.

    So I'm a mess. No matter what I do to get well, I can't. So maybe it's the genes and particular MTHFR C677T though it's just herterozygous and working at 70% (some say 50-70%) compared to homozygoys 30%. Can anyone shed light on other problem mutations and what supps I should take?

    I thought there was going to be a couple HLA genes related to mold (according to but they aren't there. Guess 23andme has taken them out.

    I should add my last homocysteine test was 5.8 (range <13).

    Here is my symptom list:

    *extreme muscle pain and inflammation (muscles spasm, ache, seize up, feel inflamed)
    *extreme fatigue
    *hair falls out easily
    *adrenal exhaustion (still tired even when thyroid is in range)
    *excessive in take of salt
    *dizziness (especially rising from the ground to stand up)
    *digestive problems (always hungry, acid reflux in lower stomach)
    *chronic sinusitis (daily)
    *systemic candida
    *excessive vaginal discharge especially after period (thin, clear), sometimes yellow
    *chronic mouth ulcers (canker) and cold sores (since a child)
    *get cold easily, hands and feet sometimes cold
    *heavy metal poisoning (mercury, aluminum, arsenic, tin, titanium. Had high levels of copper at one time but not anymore)
    heart pain (stabbing pain, tenderness)
    tenderness in chest area, near breast
    body temperature sometimes fluctuates
    easily startled
    feel wired at night sometimes even though tired
    strep (B) (Naturopath said I had high levels in my system)
    have had one seizure
    had many fainting spells as a kid and adult
    low to normal blood pressure
    diagnosed with Lichen Planus in mouth as a teen (like thrush/candida)
    break out in a sweat easily
    metallic taste in mouth
    memory problems (brain fog)
    sensitive to noise
    eyes sensitive to sunlight (easily turn red) and bright lights
    dry eyes (can't wear contacts)
    ringing in ears
    thick saliva (could be candida/other infections)
    flushed face (red)
    eyelids sometimes twitch
    dark circles under eyes
    occasional tender lymph nodes under armpits
    legs jolt me awake when sleeping
    don't seem to dream
    leg cramps
    sometimes night sweats
    knee, hip, and thumb pain (joints)
    hip dysplasia (wants to dislocate)
    Knee dislocation (twice, had surgery in 1987)
    low vitamin D
    low to normal blood pressure
    lost 3 fingernails that grew back (systemic candida/fungus) (1987)
    dry patch of skin behind ear and on back of earlobe
    dry scalp at lower back of head
    Around 1998 had CD4 Lymphopenia (low T helper cells) 600 (I'm HIV negative).
    Boil on chin (1995).

    Saliva tests show adrenal exhaustion. Mineral hair analysis shows moderate degree of adrenal insufficiency. (Phase 3 The Exhaustion Stage, final stage). Naturopath and a Medical Intuitive say adrenal exhaustion as well but this doesn't show in standard blood work.

    In May 2009 I was diagnosed with UARS. (Upper Airway Resistance Syndrome). This is a precursor to Sleep Apnea. In sleep apnea a person stops breathing many times a night and with UARS their passageway narrows making it hard to get air (like breathing through a coffee straw). During the night my heart rate stays up because I'm working hard to get enough air and therefore I'm not able to go into a deep sleep. Cpap is used for treatment but it didn't help me at all even though my heart rate settled down with use. I have sometimes wonder if I have this sleep disorder or maybe I have it in combination with something else that's making me sick.

    August 2010 I saw a mitochondria specialist and they found no problems other than I was mildly low in Free and Total carnitine. I didn't feel any better taking carnitine supplement.

    Sept. 2010 Waiting for confirmation of Vlcad which is a fatty oxidation disorder.

    Feb. 2011 Vlcad final test was negative.

    May 2012 Found out I have high fluoride and bromide levels in my body which prevent iodine from getting into my cells for proper thyroid function. I live in an area where we don't fluoridate the water. Have been avoiding toothpaste with fluoride.

    Oct. 2012 Energetic testing showed I had high levels of staph, candida, small parasites, worms, mold toxins, inflammation. I also had decent levels of the following viruses: LYV, MAV, LFV, CAV, SAV, TBV plus Lyme, Babesia and Bartonella.

    Dad died at 68 of CHF (diagnosed at 58), had his heart shocked a few times for atrial fibrillation and had 2 angioplasties, also had diabetes.
    His sisters have diabetes, one died from cancer the other suffers from alcoholism.
    His Dad died in early 50's from heart attack. Had diabetes and polio.
    His Mom died at 86 from a heart attack

    Mom died at 58 of Intracerebral Hemorrhage and Sequelae due to or as a consequence of Idiopathic Thrombocytopenic Purpura (Blood test revealed she had only 4 platelets in sample. They think a virus may have caused this but don't really know. They didn't think she had cancer).
    Mom's half siblings have cholesterol problems, one diagnosed with mild MS
    Her Dad died in WW2 of Tuberculosis
    Her Mom died at 92 of CHF and kidney failure. Also had dementia, anxiety and depression.

    Thanks for any advice,

  2. ahmo

    ahmo Senior Member

    Northcoast NSW, Australia
    Hi Cheryl. My profile's a lot like yours. I'll return tomorrow and share my protocols and sources of info. having server trouble here, might be 3 copies of this. cheers, ahmo
  3. musicfreak


    Thank you Ahmo. I would love to hear about your protocol and sources when you are able to report. I've also added in my symptom list for the heck of it.

    Take care,

  4. ahmo

    ahmo Senior Member

    Northcoast NSW, Australia
    1) You can go to Promethease and upload your results to get a full read-out of your genes, way more info than you'll probably want. (Though when I reread your family history, you might well want a lot.)This was where the small summaries I've pasted below come from, except for MTR and AHCY, which came from Heartfixer.

    2) Heartfixer offers a consolidated form of Amy Yasko's protocols. It includes the diagrams of the various cycles affected by these defects, lists sups.

    3)Amy Yasko's free ebook, comprehensive info and supplement recommendations:
    Also, you can register for Yasko forums, w/ excellent help.

    4)Ben Lynch's Basic and comprehensive for MTHFR
    Sterling Hill: extras not included at Lynch's site. Both of these have valuable info in the comments sections.

    Also, there's a v handy extension for Firefox called SNPtips. When you upload your 23andme results into it, it then highlights your SNPs if you're reading something about them, so you don't have to refer to your notes to know this is about you. Called SNPtips.

    We share some of the defects re neurotransmitters, mood swings due to overly active neurotransmitter cycling. I got a lot of help with this when I supplemented for pyroluria, esp. TMG, p5p. But when I added Yasko's suggested low-dose lithium orotate (Not the high-dose Lithium carbonate rx for bipolar) I noticed a much awaited shift. No more crying too easily, feeling much more balanced.

    You wrote that you know you need folic acid. I hope you know that you need NOT folic acid, but Methylfolate.

    Re Lyme disease: Here are links to 2 pdfs from Dr. Klinghardt, who's a leader in treating lyme. He believes that it's so prevalent in autism because it's a congenital illness, not only from contact w/ vectors. Many of the mothers on GAPS forums are using his protocols. 2010.pdf…

    It looks like starting w/ Freddd's methylation protocol is a good beginning. Is the carnitine you're using fumarate? It makes a difference. As do the sources of B12, including Adeno B12.

    I think this is enough info for the moment, there's a lot for you to digest. And I'm at my limit for the moment. ahmo

    COMT V158, COMT H62H +/-
    VDR Taq ++
    MAO +/-
    MTHFR C677 +/-
    MTR A2756G +/-
    MTRR A66G +/+
    BHMT 02, 04, 08 +/-
    AHCY 01, 02, 19 +/-

    rs4680 - COMT V158M (Risk Allele: A)
    s4633 - COMT H62H (Risk Allele: T)

    This gene helps break down dopamine and norepinephrine. A defect will cause higher dopamine due to slower breakdown. Implicated in ADD/ADHD. More susceptible to dopamine fluctuations, therefore mood wings. People without COMT mutations are generally more even tempered.

    rs1544410 - VDR Bsm (Risk Allele: T)
    rs731236 - VDR Taq (Risk Allele: G)

    Vitamin D receptor. VDR Fok is involved with Blood sugar regulation. [Fok Not Tested] VDR mutations oppose COMT mutations in the regulation of dopamine levels. A VDR mutation means that a person is less sensitive to methyl group supplement levels. (Mood swings.) A VDR mutation can result in behaviors opposite to a COMT mutation. See Dr. Roberts comments at Taq: Vitamin D Receptor Taq Abnormality

    rs6323 - MAOA R297R (Risk Allele: T)

    Slower breakdown of Serotonin. Can lead to high/low cycling of neurotransmitter. Mood swings, aggressive behaviors. ACE deletions will also increase anxiety and lower frustration thresholds.
    rs1801133 - MTHFR C677T (Risk Allele: A)
    rs1801131 - MTHFR A1298C (Risk Allele: G)

    MTHFR mutations are the centerpiece of the work by Yasko, Rawlins and others, and is the most important to understand. An MTHFR mutation can starve the entire methylation cycle, which has some very large health impacts.
    The C677T mutation is associated with a general set of problems: elevated homocysteine, increase in heart disease, increased stroke, increased deep vein thrombosis, peripheral neuropathy, placental vascular problems (stillbirth), preeclampsia, neural tube defects, cleft lip.
    The A1298C mutation is assoicated with a second set of problems: depression, anxiety, irritable bowel syndrome, fibromyalgia, chronic fatigue, migraines, dementia, nerve pain, schizophrenia, parkinson’s, tetrahydrobiopterin (BH4) problems. Although not addressed by Yasko, if your Promethease report includes Gs223 or Gs224, you may have additional BH4 impairment.
    A person who is compound heterozygous (a single C677T mutation and a single A1298C mutation, each on a different strand) will see symptoms from both defects, but the symptoms tend to be more severe. Rawlins also believes that blood clots are more prevalent. As bad as that is, a person with a single mutation on one gene and a double mutation on the other can be worse. A person who is compound homozygous (double mutation on both genes) is also worse.
    rs1801394 - MTRR A66G (Risk Allele: G)
    rs10380 - MTRR H595Y (Risk Allele: T)
    rs162036 - MTRR L350A (Risk Allele: G) [my chart reads K350A rs162036]

    Necessary to regenerate Methyl-B12 for use by MTR. Mutation can cause shortage, suggesting a need for more B12.

    rs567754 - BHMT-02 (Risk Allele: T)
    rs617219 - BHMT-04 (Risk Allele: C)
    rs651852 - BHMT-08 (Risk Allele: A, 23andMe: T)

    The product the BHMT gene is central to the ‘short cut’ through the methylation cycle, again helping to convert homocysteine to methionine. The activity of this gene product can be affected by stress, by cortisol levels and may play a role in ADD/ADHD by affecting norepinephrine levels.
    Yasko believes that believes BHMT-02 and BHMT-04 play a role in the gut environment. Yasko also believes that BHMT-08 is related to the impact that psychological stress has on a patient’s attention levels.

    When the MTR A2756G defect is present, MTR is always on, using up methyl-B12 faster than MTRR can regenerate it. The consequence is deficient methyl-B12. B12 blood levels may be normal, but as levels of methyl-B12 will be low, normal B12 physiology cannot be carried out. Homocysteine levels will typically be elevated. SAMe generation and methylation in general will be compromised. We can treat the MTR up regulation by:
    a. Supplementing you with methyl-B12.
    b. Measures designed to increase formation of methyl-B12.
    c. We can also bypass the dysfunctional MTR step by stimulating the “backdoor” BHMT reaction, which converts homocysteine directly in to methionine (more on this approach later).
    d. When we do not need to limit sulfur intake (CBS normal or under control with low urine sulfate readings) we can simply supplement you with SAMe, our most important methyl donor, which is otherwise formed from the methionine generated by the MTR/MTRR reaction.
    AHCY S-Adenosylhomocysteine Hydrolase
    S-Adenosyl Methionine (SAMe), the key methyl donor generated from methionine, is metabolized in to S-Adenosyl Methionine, and then on to homocysteine by AHCY. Individuals (+) for both AHCY and CBS often have low baseline urine sulfate levels, which then rise and fall in response to treatment. Early on the levels rise, as the “bottle neck” abnormal AHCY enzyme has been “limiting the supply” of homocysteine. Once the cycle starts to spin, homocysteine is made available to CBS, and urine sulfate will rise. Later, in response to a low animal protein/low sulfur diet, urine sulfate levels will fall. Defects in AHCY are addressed by measures designed to improve overall Methyl Cycle function, such as Methyl support RNA 1/8th dropper per day.
    SickOfSickness likes this.
  5. baccarat

    baccarat Senior Member

    I don't think the genes are the key problem although they could be a predisposing factor.
    With this illness there are a lot of unknowns but a few things we do know. For those of us who have been sick for years, simply restoring the methylation cycle or taking supplements won't help much if there are viral or retroviral, bacterial, parasitic infections, systemic yeast, biotoxins, high burdens of heavy metals which act as blocks, instead these need to be directly removed.
    Lotus97 and shannah like this.
  6. musicfreak


    ahmo Thank you very much for your reply.

    I haven't uploaded my results to Promthease. When I checked out the sample it showed health conditions you are prone to. I don't want to know that right now as I don't need the extra worry. I haven't checked any of my 23andme results, only have downloaded the raw data.

    Thanks for all your other links. I have come across those websites before and now I'm going back to read them more thoroughly.

    Yes, I realize I don't take folic acid but the Methylfolate and I know there are some other forms.

    I can't remember the kind of carnitine I was taking. It was only available as prescription here in Canada as of a couple years ago. Now recently it's finally been approved to buy in health food stores.

    Thanks again for all your info.

  7. musicfreak



    I was a little uplifted to get my results to find I had a few problems with my genes and had some hope that restoring the methylation cycle might help me. I thought doing that helps to get rid of infections and toxins etc.? I know doing that on it's own will not heal me completely as I also need to target these problems directly. I'm going to start some new supps soon for my problems and the methylation cycle and hope it helps.

    I've been trying to directly treat my problems for 29 years now. I really hope adding supps for the methylation cycle helps.

    Anyone else have any advice on what I should do? Seriously, I'm at my wits end. This has really affected my life in all areas in a big way. I want to have a normal life.

  8. baccarat

    baccarat Senior Member

    the small methylation study done by Rich and Dr Nathan showed that people who had some of those problems other than methylation, say mercury for e.g, had to deal with those in order to get better. My personal experience was similar.
    It seems to me that getting the priorities right is also an important factor. For e.g. if you live in a moldy house and you have a problem with mold, addressing that would be a key priority. I personally believe that removing biotoxins (from mold or lyme) would always a top priority, as those tend to raise immune system reactivity and make everything else more difficult. Then I also read about some with autism for e.g. that started to get better only after chelating metals. Also in addressing infections, some doctors suggest a certain order of treatment etc. So it seems to me that if your doctor can help you get the priorities right (and hopefully the correct treatment for a certain problem) for your particular circumstances, then it could make things easier for you.
  9. Lotus97

    Lotus97 Senior Member

    United States
    What if someone is both COMT (+/+) and VDR Taq(+/+)? Heartfixer doesn't seem to address that combo unless I missed something.
  10. musicfreak



    Thanks again for your reply. I understand what you're saying. Problem is my health problems are a major undertaking as I have so many problems and my family doctor isn't familiar with half of it and a lot of things don't show up on regular testing. I know a good doctor for Lyme (an LLMD) who also is familiar with Klinghardt but I can't afford to see him. I'm sure if I gave him my genetic results and told him of Ben Lynch in Washington he may consult with him as he's a very open minded doctor. But for now I will have to treat myself by following a methylation protocol, taking supplements to fight infection and get back to Cutler's protocol to detox heavy metals until I can afford to see that naturopath.

    I do agree about treating the mold toxins and Lyme first. I spoke with a doctor in Washington who told me how to deal with the mold toxins. I'm living in a place now where there is no mold but my previous place did have some. When I looked at the place they had the window open so when I went in there it didn't smell musty. I realized there was a problem after I moved in. But I don't know if this place really affected my health all that much as I've always felt the same where ever I lived but obviously mold is not a good thing so glad I'm out of there.

    I always thought there was one thing that was causing so much havoc in my body and hoped it was the methylation cycle. I will keep plugging along.

    Thanks for your suggestions.

  11. Lotus97

    Lotus97 Senior Member

    United States
    I don't think you necessarily have to treat other health problems first (although some might), but you will need to go slower in regards to dosages. With metals, they will be released from methylation so it would be good to take binders. With viruses or infections such as Lyme, inflammation can be an issue with methylation.
  12. musicfreak


    @Lotus Thanks for your response. I was thinking of doing the Cutler protocol again. I really wasn't noticing any difference (I only did it a couple months though) and taking it around the clock was hard for me. So I was debating about Chlorella. I know Cutler doesn't feel it's a proper chelator but seems it's helped a lot of people. I did take it years ago to help with body PH and I didn't have any reactions to it. So we'll see. I do have some DMSA and ALA left. I ended up not using the DMSA as I heard it can make yeast problems worse.

    I'm going to finish reading Amy Yasko's book and go from there. I think I'm going to do as you said, treat the methylation and other problems but just go slow and stick to it as changes won't happen over night.


  13. Lotus97

    Lotus97 Senior Member

    United States
    Mercury detoxification is a controversial subject. Some people (Cutler) say ALA is the safest, but I've heard others say since it's single thiol chelator that it's not so good. I've also heard of people using chlorella without a problem, but just because you don't experience an adverse reaction to a chelator doesn't mean it isn't causing a problem. I've heard from two people who were able to take ALA and NAC without a problem even though they tested positive for mercury toxicity. Since I'm not sure what my situation is, I decided to stop ALA and NAC for now even though they don't seem to bother me.

    I have Lyme too so I've been doing research on that. Klinghardt is a controversial figure. I'm not going to say anymore than that, but I've heard mixed things about him. I think I'm going to try Buhner's protocol for Lyme. Buhner actually recommends chlorella for binding to the toxins released from the treatment. One thing that should be said about chlorella is that 30% of the population has an intolerance to chlorella that has nothing to do with mercury so it can make some people very sick.
    Some people do have quick results with methylation, but most people experience an initial worsening of symptoms. Make sure to familiarize yourself with the symptoms of low potassium/hypokalemia and have some potassium supplements on hand in case you need them. Not all adverse symptoms from methylation are due to low potassium though.
  14. musicfreak


    @Lotus I know Mercury is very controversial. I just don't know what to do sometimes. Some people say this, some people say that. I've never heard ALA is a single thiol chelator. Very surprising cause Cutler is against single thiols like chlorella.. I think some people are more sensitive to certain chelators and depends how toxic they are. I just thought of doing chlorella since I really hate taking Cutler's protocol during the night.

    I've heard Klinghardt is controversial as well. I don't really know. I haven't read much about him. Sorry to hear you have Lyme also. I was researching Buhner's protocol too but got turned off because I read a post of some guy who had a heart attack after being on it awhile. He believes the amount of calcium he was consuming from the resveratrol was a factor. There has been lots in the news recently about how taking too much calcium can cause build up in the arteries and cause a heart attack so I'm a bit leery. I have reserved the book at the library to read about his protocol more. This is the post, his is the 7th one. Could be the Buhner's protocol had nothing to do with it but I still don't like taking that much calcium.

    I have read some people struggle with methylation treatment. I don't know what will happen with me since I never notice change in anything I try. I try to stay an even keel though as I've been so hopeful before about treatments and be let down.

    Thank you for the warning of potassium. I already have an issue with that as I get cramps in my legs and since I started supplementing they've been much better.

    Take care.
  15. Lotus97

    Lotus97 Senior Member

    United States
    I did a Google search and all the sources I see are saying that ALA is a di-thiol chelator/has two thiol groups. The person who told me ALA was a single-thiol chelator is knowledgeable in mercury detoxification, but maybe they were wrong. (I edited my previous post since all the sources do seem to say it's a two thiol chelator. That person told me OSR and microsilica were better. However, alpha lipoic acid does cross the blood brain barrier which makes me a little wary. I guess it could possibly remove mercury from the brain, but it could also deposit mercury in the brain. I want to do more research before I make any decisions. Some people swear by Cutler's method, but others have voiced skepticism.

    I've also heard mixed things about clay as a binder. Some people have said calcium bentonite specifically has worked well for them while I've heard others say zeolite and bentonite have caused them problems and there's also concerns about contamination. I've also heard concerns about chlorella being contaminated.

    Source Naturals adds dicalcium phosphate to their resveratrol tablets. I couldn't find any information about calcium naturally occurring in resveratrol. It's actually not the resveratrol that is what's needed for Lyme (although it could help for inflammation). Buhner recommends the whole herb (Japanese knotweed/polygonum cuspidatum) which has other constituents besides resveratrol. Source Naturals does sell it in capsules which don't have calcium. Paradise Herbs also sell a full spectrum extract which Buhner now recommends since he said some people had side effects with the Source Naturals brand.

    In regards to calcium, it's important to take vitamin K2 with it. Especially if you are supplementing with vitamin D which increases blood levels of calcium. Vitamin K2 helps get the calcium out of the blood and into the bones. That study about calcium was flawed according to Life Extension magazine
  16. musicfreak


    Hi Lotus,

    I figured ALA being one thiol was wrong cause it's the mainstay in Cutler's protocol and he's against single thiols like chlorella. I think it's good ALA crosses the BBB as if you have mercury there you want to get it out, you just have to do it safely. A lot of chelators don't cross the BBB. I know what you mean about Cutler's protocol, some swear by it and some think he's wrong with the small continuous doses but he says doing it that way there is less redistribution than one or two larger doses a day.

    I heard about OSR a few years ago but I can't find it anywhere on the internet. I found this link in a google search and it says that the FDA banned it. You can see a couple comments by Cutler there. He doesn't think it's a good product. I noticed there's a Yahoo group on it and there's hardly been any activity so I don't think it's being made anymore. As for microsilica I think you mean Diatomaceous Earth (food grade)? It's suppose to pull heavy metals out of the body, I'm not sure about the BBB though. I have a feeling not. I'm taking it mainly to help kill parasites (it slices and dices them!) but I know it helps with heavy metals and candida. What I like about it is it's the only thing that helps me be more regular. I take 1 tablespoon twice a day in almond milk. Energetic testing said I had parasites so I'm taking it in case and it's cheap. I actually think everyone has parasites. Btw, Cutler doesn't agree with DE either. He's more for bentonite clay and charcoal.

    I've always heard clay was good but never tried it. As for zeolite I tried it for a while and got a few headaches from it so it was doing something. But then I started reading negative stuff about it. I'm not sure what it was, maybe that it can't cross the BBB (but I wonder if it did since I got headaches) but in doing a search now there seems to be a mix of yes and no as to whether it does or not. If I find out what the reason why it turned me off of it, I'll get back to you on it. I know also there is discrepancy on what is best the liquid or powder. Now, in searching I've read more good things about it so I don't know! lol!

    Lotus, thank you for correcting me on the Resveratol. I think that post confused me as originally I thought Resveratol had something to do with grapes but didn't know another name for it was Japanese Knotwood and thought it contained calcium. So I see that calcium was just added in. If I do the protocol I will get just pure JK. So I'm feeling a bit more optimistic now about Buhner's Protocol. I was told it's one of the cheapest protocols to do. I'm going to look at his website more tonight. I found this link for another source of JK on Buhner's site

    As for the calcium, I never heard any backlash about it. I heard about it years ago and then again a couple months ago so I just decided to be on the safe side to eat calcium rich foods rather than supplement. I'm on a candida diet so that's kinda hard but I was taking kefir before. Now I'm taking a break from it so may have to add in a calcium supplement as I'm not getting much being on this strict diet. I always supplement with Vit D, but never have with Vit K. That would be a safe bet if you say it keeps it out of the blood and into the bones.

    Take care.

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