I've not been here for a while, due to unrelated tasks, so I may have missed some previous discussions. (For friends who worry, this is not a health problem. I'm actually a little better.) However, when I see research that affects T-cell types, metabolism and immune function I can hardly ignore it. This article just appeared on Medical Xpress. Standard mainstream medicine looks for autoantibodies to detect autoimmune diseases. These are produced by B-cells and plasma cells. T-cells tend to be neglected, even though there are plenty of papers describing cases in which T-cells invade tissues where they are not normally found in healthy people. For some time I've been playing with the hypothesis that autoantibodies are often the result of immune attack on a category of host cells, not the cause. By using autoantibody levels as diagnostic criteria we may have made it impossible to find the cause, or at least complicated searches for etiology. As for testing whether your T-cells are conventional alpha-beta or unconventional gamma-delta, that just doesn't happen in typical medicine. These are the kind of lacunae in medical research thinking I've been looking for over a period of years. It became obvious years ago that doing more of the same was not going to address the causes of many medical problems, and not just those that end up on this forum. This could be a breakthrough.