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Mouse retroviruses and chronic fatigue syndrome: Does X (or P) mark the spot?

Discussion in 'XMRV Research and Replication Studies' started by mojoey, Aug 23, 2010.

  1. mojoey

    mojoey Senior Member

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  2. mojoey

    mojoey Senior Member

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    So what I get is that the X-type can only infect human cells, but the P-type both mouse and human cells. I heard one leading CFS doctor say that the P-type is likely much more virulent that the X-type, but I'm not aware of the basis for this.

    Both use the XPR1 receptor to mediate cell entry, so will future therapy comprise of XPR1 receptor-lacking stem cells (analogue to the CCR-5 receptor-lacking stem cells that cured AIDS patient?)

    I also love that the commentary ends with this bit:
     
  3. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    HI

    The reference for the other retrovirus in post 2 is:

    22. Xu L, et al. (2003) Does a betaretrovirus infection trigger
    primary biliary cirrhosis? Proc Natl Acad Sci USA
    100:8454–8459.

    I have not read this, but it might mean that XMRV is the fourth human retrovirus, and that the only path to proof of causation is a successful clinical trial with antiretrovirals.

    Bye
    Alex
     
  4. Rrrr

    Rrrr Senior Member

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    YES, clinical trials now!!!!!!!!!!!!!!!

    i think this has to be our chant.

    also, i had never heard of the ARV "emtracitabine" -- as mentioned in the quote from joey's post. has anyone else heard of it?

    i thought that the 3 meds found to work in vitro (check on the doses, i'm not sure about them!!!!!!!!!) were:
    AZT: 300 mg, 2x/day
    Raltegravir (Isentress): 400 mg, 2x/day
    Tenofovir (Viread): 300 mg, 1x/day

    This below study by Dr. Singh states that raltegravir is the most effective against xmrv in vitro, and dr coffin and others have told me it is the one with the least side effects in vivo.
    "Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome"
    http://www.aidsmap.com/en/news/7783CFCE-5022-40C8-AE08-0A99D440CAC2.asp
     
  5. Wasbeer

    Wasbeer

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    Chanting along :victory:
     
  6. anciendaze

    anciendaze Senior Member

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    If the Lo/Alter paper was the elephant in the room, that hypothesis has been the dinosaur nobody admitted seeing. Complementation and recombination of multiple infections is finally out there as a possible cause of human disease, including the baffling affliction called CFS/ME.

    Added: In reading through the earlier post, this time I caught an indirect implication.
    By mentioning MMTV they indirectly bring in a possible HMTV, without explicitly mentioning relevance to breast cancer research. The implications keep growing.
     
  7. mojoey

    mojoey Senior Member

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    Reading over the commentary, I can't for the life of me figure out if the polytropic MLV is endogenous or exogenous. I've heard CFS researchers imply that it is "definitely" exogenous, but the commentary muddles that a bit
     
  8. anciendaze

    anciendaze Senior Member

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    It is definitely exogenous. It should not be able to reinfect the species from which it originated otherwise. That is the distinction between xenotropic and polytropic.

    Remember, these names are all only strong hypotheses at this point. Everything will need to be nailed down. Even so, implications run off in many directions. I don't expect anyone to declare the excitment over anytime soon.
     
  9. usedtobeperkytina

    usedtobeperkytina Senior Member

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    Clay, Alabama

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