Freddd
Senior Member
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At long last I have some approximate answers about the effects of ratios of different brands and forms of b12. This is a question that has been up for a long time. It may explain why CyCbl and HyCbl appear able to block MeCbl and AdoCbl. As I have suspected for some years AdoCbl also can block MeCbl.
Through the years various people have indicated a need for different proportions of AdoCbl to MeCbl. I had started out with AdoCbl once a week and up to daily at every dose in a mix. I have found that if the amount of the lesser quantity falls below 20% or so it appears to have no effect. So at 50-50 both have some effect for me but not optimal. The same happens with a 5 star MeCbl combined with a less effective brand. When the 5 star MeCbl gets down to 20% or so of total all it's specific benefit goes away and startup can happen all over again.
So CyCbl and HyCbl can block MeCbl and/or AdoCbl when either of those falls below 20%. AdoCbl can block MeCbl at 20%. MeCbl can block AdoCbl at 20%. but then behaves like straight MeCbl with some limited conversion to AdoCbl. Three star MeCbl can block 5 star MeCbl at the same 20% or so.
So for me now, I am back to a single dose of AdoCbl a week, just as I had accidently found 10 years ago. I take a single dose of 25-50mg aver several hours in place of one of my MeCbl injections. I'm still trialing the optimum amount. The point is for it to be fully effective it has to be the more than 50% type of b12 in circulation for several hours. Too much AdoCbl for too long and I go into partial methylation block or worse.
However, it takes trials for an individual to determine what is optimum ratios for themselves. Based on very limited experience I would be inclined to say take the doses of different kinds of B12 at different times per day so that each can be distributed best to the tissues.
For me, that appears to be substituting one 25-50mg sublingual dose over 3-4 hours of AdoCbl for one 10mg MeCbl injection each week.
BE IN GOOD HEALTH
Through the years various people have indicated a need for different proportions of AdoCbl to MeCbl. I had started out with AdoCbl once a week and up to daily at every dose in a mix. I have found that if the amount of the lesser quantity falls below 20% or so it appears to have no effect. So at 50-50 both have some effect for me but not optimal. The same happens with a 5 star MeCbl combined with a less effective brand. When the 5 star MeCbl gets down to 20% or so of total all it's specific benefit goes away and startup can happen all over again.
So CyCbl and HyCbl can block MeCbl and/or AdoCbl when either of those falls below 20%. AdoCbl can block MeCbl at 20%. MeCbl can block AdoCbl at 20%. but then behaves like straight MeCbl with some limited conversion to AdoCbl. Three star MeCbl can block 5 star MeCbl at the same 20% or so.
So for me now, I am back to a single dose of AdoCbl a week, just as I had accidently found 10 years ago. I take a single dose of 25-50mg aver several hours in place of one of my MeCbl injections. I'm still trialing the optimum amount. The point is for it to be fully effective it has to be the more than 50% type of b12 in circulation for several hours. Too much AdoCbl for too long and I go into partial methylation block or worse.
However, it takes trials for an individual to determine what is optimum ratios for themselves. Based on very limited experience I would be inclined to say take the doses of different kinds of B12 at different times per day so that each can be distributed best to the tissues.
For me, that appears to be substituting one 25-50mg sublingual dose over 3-4 hours of AdoCbl for one 10mg MeCbl injection each week.
BE IN GOOD HEALTH
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