Discussion in 'Other Health News and Research' started by natasa778, May 9, 2014.
I am looking at environ factors that can influence/downregulate NRF2, and can't get further than retroviruses (surprise, surprise). Ideas?
Minocycline to the rescue?
Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice
Maybe it is this genetic weakness which causes more autism to be seen among the children at least of those who have ME/CFS if my observations on this have been correct (I think autism is a lot higher among our children). Maybe many of us are carrying a gene affecting these immune cells?
Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?
From, the abstract http://pediatrics.aappublications.org/content/133/5/e1405
Possible, but I very much doubt it is about them or 'us carrying a genetic weaknes' - given the number of genetic studies all coming up empty (ie one would expect it to have been picked up by now). More likely imo that something is actively interfering with its function ...
Looking into things that regulate/influence Nrf2, I have come across this novel drug - has been in use for many decades in Russia, now being repackaged and re-marketed it seems (but only to Central and East Eu countries http://www.bachpharma.com/origins.php ?? )
Can't vouch for the accuracy of this but someone has put a lot of leg work in :
The pivotal role of Nrf2. Part 2 – foods, phyto-substances and other substances that turn on Nrf2
I'm off to whip up a little curcumin, piperine and ginger concoction!
Interesting that this Russian drug I just posted about has been looked into for this:
An inflammation in adipose tissue study. Impact on insulin resistance and glucose tolerance with gavage administration of GVT® (GVT®) in FVB/N mice
There was some talk recently about adipose tissue in ME/CFS if I remember correctly?
Metabolic disorders, oxidative stress, mito dysfunction and neuroinflammation do all appear to be linked although how closely is debatable :
Plus in diabetes, minor bouts of hypoglycemia have been shown to cause neurodegeneration resembling that seen in Alzheimers :
Brain atrophy linked with cognitive decline in diabetes
Re ME/CFS - were you thinking of the study associating leptin with the level of fatigue?
I think there may be several genes involved in ME/CFS (maybe affecting methylation or maybe affecting immunity or combos of genes making us susceptable) and hence why just looking for one hasnt yet been easily found.
Faulty genes more easily allow something else to come along and knock something out.
You can also try a Google Site Search
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