Mitochondria control stem cell fate

[hixxy]

Date: October 27, 2016
Source: Technical University of Munich (TUM)

Summary:

If the powerhouse of the cell, mitochondria, is disrupted, stem cells in the gut suffer, researchers have discovered. The human intestinal system covers an area of approximately 300 to 500 square meters due to its many protrusions (villi). This inner intestinal wall full of tiny bumps renews itself completely once every four to five days, a process which is guided by stem cells. Mitochondria are the powerhouse of a cell and provide energy through respiration, and play a crucial part in this process.

https://www.sciencedaily.com/releases/2016/10/161027123402.htm#.WBVH-jmSFcA.facebook

 

[alex3619]

It make sense that in a disorder with impeded energy production there would be gut involvement. I think the brain is likely to be the most impacted though. Where the gut impact may occur is a lower than normal repair rate, predisposing to both gut issues and salicylate intolerance.

Any fast replicating cells are likely to be affected though.