Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
Discuss the article on the Forums.

Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolam

Discussion in 'Other Health News and Research' started by nanonug, Oct 30, 2012.

  1. nanonug

    nanonug Senior Member

    Virginia, USA
    Pain Med. 2010 May;11(5):781-4. Epub 2010 Mar 22.
    Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide.

    CalabrĂ² RS, Gervasi G, Marino S, Mondo PN, Bramanti P.

    IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.


    Pudendal neuralgia is a cause of chronic, disabling, and often intractable perineal pain presenting as burning, tearing, sharp shooting, foreign body sensation, and it is often associated with multiple, perplexing functional symptoms.

    We report a case of a 40-year-old man presenting with chronic pelvic pain due to pudendal nerve entrapment and successfully treated with palmitoylethanolamide (PEA).

    PEA may induce relief of neuropathic pain through an action upon receptors located on the nociceptive pathway as well as a more direct action on mast cells via an ALIA (autocoid local injury antagonism) mechanism. As recently demonstrated in animal models, the present case suggests that PEA could be a valuable pharmacological alternative to the most common drugs (anti-epileptics and antidepressants) used in the treatment of neuropathic pain.
    Comment in

    PMID: 20345619

See more popular forum discussions.

Share This Page