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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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So.... it is worth me listening to this 2 hour interview or not? Only there seems to have been very little reaction to what she had to say. Thanks.
is suggests the possibility of HERVs) [My comment - If I remember correctly - HERVs don't have ENV (envelope) sequences, as they are not full viruses.]
I can't remember how it all began now... What made Judy look at XMRV for CFS patients in the first place?
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Here we study the control of ERVs in the commonly used C57BL/6 (B6) mouse strain, which lacks endogenous murine leukaemia viruses (MLVs) able to replicate in murine cells. We demonstrate the spontaneous emergence of fully infectious ecotropic4 MLV in B6 mice with a range of distinct immune deficiencies affecting antibody production. These recombinant retroviruses establish infection of immunodeficient mouse colonies, and ultimately result in retrovirus-induced lymphomas. Notably, ERV activation in immunodeficient mice is prevented in husbandry conditions associated with reduced or absent intestinal microbiota. Our results shed light onto a previously unappreciated role for immunity in the control of ERVs and provide a potential mechanistic link between immune activation by microbial triggers and a range of pathologies associated with ERVs, including cancer.
Thanks Bob for your efforts. I might take another attempt at listening, can't say I'll absorb any of it, and I've had enough of the why's and wherefore's and speculation and hypothesising over something that wasn't anything but wasted so much time and sparked such consternation. What did she have to say about the accusations and sacking incidents? Thanks.
Thanks Bob for your efforts. I might take another attempt at listening, can't say I'll absorb any of it, and I've had enough of the why's and wherefore's and speculation and hypothesising over something that wasn't anything but wasted so much time and sparked such consternation. What did she have to say about the accusations and sacking incidents? Thanks.
She didn't speak much to the firing and subsequent trial. Was asked if she ever got her notebooks back, and she said "no". And that was about it.
I think it is worth listening to, really just about XMRV - her study and the Lipkin study. A lot of detail about both. Very specific questions, better if you are scientifically minded (which I am not, but still glad I heard it). If you are fascinated by GAG sequencing, HERVs or cohort selection, you will love it. Really, really puts to rest idea that XMRV the cause of CFS. I wish she had gotten into what she is working on now, and what Lipkin is up to, but unfortunately that was not addressed.
Does any one have any thoughts on this?
I haven't followed the XMRV/HGRV debate for a long while now and I am not a science person, but I do recommend the podcast. It was quite interesting to me.
When asked why some people improved on ARVs, she gave the reasoning that was presented above in other posts. Plus she said that neither Michael Snyderman nor Jamie Deckoff Jones had been diagnosed with "CFS". I was pretty sure he was saying he did have ME in addition to CLL. I know Jamie's main diagnosis was Lyme, but I also thought she has said she has ME.
I don't know any statistics, so I can't really evaluate what she was saying about the following. She said that XMRV IS NOT A HUMAN INFECTION. She also said at least that it hasn't been found in other animals, and I think I remember her also saying XMRV does not infect other animals either. /Interesting as I didn't read the transcript or listen to the broadcast but curious about your quote of Mikovits. Dr. Snyderman is an oncologist and hematologist and Dr. Jamie was ER director ...I believe. These two people are both clinicians and if anyone who could assess a condition of ME/CFS would be those two and not a researcher. Big difference between the two professions. Besides Lyme disease is associated with a bacteria infection which ART would be ineffective. Since there are no definitive bio markers for this illness, even Mikovits cohort could be suspect!
Don't understand Mikovits comments on animals as there were studies with infected with xmrv rhesus macaques and pigtailed macaques although one study showed antibody production to neutralize xmrv.
http://www.retrovirology.com/content/8/S1/A219
http://jvi.asm.org/content/early/2011/02/16/JVI.02411-10.abstract
Curious
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