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"Microglia Disrupt Mesolimbic Reward Circuitry in Chronic Pain"

Discussion in 'Other Health News and Research' started by Kyla, Jun 11, 2015.

  1. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    http://www.jneurosci.org/content/35/22/8442

     
    Last edited: Jun 11, 2015
    rosie26, garcia, adreno and 5 others like this.
  2. aimossy

    aimossy Senior Member

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    Medical News Today article on this paper (research done in mice)
    http://www.medicalnewstoday.com/articles/295135.php

     
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  3. Kyla

    Kyla ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ

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    This seems like it would line up with the effect of LDN for fibro?
     
  4. Marco

    Marco Grrrrrrr!

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    That's Jared Younger's working hypothesis I believe.
     
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  5. voner

    voner Senior Member

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    this is an open access paper.

    here is a quote from the discussion section of the paper

    Moreover, this work affirms the importance of microglial activation in modulating reward behavior and suggests microglial inhibitors as an effective therapeutic for disrupted DA transmission.

    i'm waiting to see what the comments are from other researchers in the field. I could not find any, yet.
     
  6. Marco

    Marco Grrrrrrr!

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    On a related note, someone (many thanks) forwarded this paper to be which describes a mouse model of FMS/CFS in which chronic stress induces neuropathic pain via activated microglia in the spinal dorsal horn (paragraph breaks added).

    http://www.ncbi.nlm.nih.gov/pubmed/24852223

    Whether or not chronic neuropathic pain is an adequate model model for 'CFS' or that chronic stress is a relevant 'stressor' is debateable. It's also interesting that microglial activation in specific spinal regions may have been in response to behavioural changes (increased rearing on the hind legs leading to increased muscle tone/strain.

    Dopamine attenuation is also implicated :

     
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