I've been experimenting with methylb12 alone. Every few days I'll take a 1/4 of an ENZY in the morning with breakfast (hold against gums for about 45 minutes) and just see how it makes me feel. I think my reaction is best described this way: Within 1 hour after taking: A "buzzy" kind of mental brightening. My head actually feels "cool" as if a "cool" breeze is reaching it for the first time in a while. I know that sounds very odd. Some parts of it are nice. Other's not so much. I wouldn't call it necessarily enjoyable. About 2 hours after taking: I start to get very sleepy. I could seriously crawl up in a corner and take a nap right here in my office. 4-6 hours after taking: Things settle down and I feel a better, more tolerable sense of being. This feeling can sometimes last the rest of the day. That pattern is very constistent in the absence of other supplements. Any theories or ideas as to why? I like to take supplements in low doses individually these days so I can understand how they make me feel one by one before combining with other things.