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Metabolism in chronic fatigue syndrome

Discussion in 'Latest ME/CFS Research' started by Bob, Oct 29, 2014.

  1. Bob


    England (south coast)
    Metabolism in chronic fatigue syndrome.
    Armstrong CW, McGregor NR, Butt HL, Gooley PR.
    Adv Clin Chem. 2014;66:121-72.
    DOI: 10.1016/B978-0-12-801401-1.00005-0

    alex3619 likes this.
  2. Snow Leopard

    Snow Leopard Hibernating

    South Australia
    It might be an interesting review, but it is a chapter in a paywalled book, so I probably won't be reading it.
    Bob likes this.
  3. Ema

    Ema Senior Member

    Midwest USA
    I haven't read the entire thing yet but part of this caught my eye regarding unregulated 5-HTP receptors in the hypothalamus. I've always suspected that my serotonin level was not low (as speculated in major depression) but there was something else going on with that system given my abysmal response to any sort of SSRI/SSNRI/etc drug.

    This article (from 1992) seems to address this:

    Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome.

    The whole article is located at the link.

    Strangely enough, this also seems to affect prolactin by increasing levels by some 400% (vs 100+% in controls). The post viral fatigue group also had side effects from the challenge including nausea and lightheadedness which could easily be related to the prolactin surge as well as other things.
    Last edited: Oct 29, 2014

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