Hello Do anyone know why some doctors recommend starting with one daily dose? My doctor wants me to divide the dosage in 4 daily dosages because of the half-life. He has little experience with Mestinon and I see that most other on this forum start with one dosage and increase to two dosages after a week (+/-). I also see that many uses 4 daily dosages after a while. I hope anyone can explain the rationale behind the starting dosage when starting with Mestinon.