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Melatonin: makes OI worse?

Discussion in 'Problems Standing: Orthostatic Intolerance; POTS' started by Sasha, Nov 18, 2010.

  1. Sasha

    Sasha Fine, thank you

    I have a questionable diagnosis of OI (acc. the poor man's tilt test, confirmed by my GP I have it; according to a cardiologist I was sent to who insisted on a 10-min test only, I haven't).

    However, I was prescribed melatonin two days ago to help me sleep and I'm having what seem to me to be florid OI symptoms that I've not had before; feeling slightly light-headed on standing and within minutes of being on my feet, finding that I'm stooping over and urgently feeling the need to lie down. I've spent most of the last two days lying down because even sitting with my feet up is too much.

    I've found several links suggesting that melatonin would make OI worse, e.g. this in the Journal of Physiology and this on the Dysautonomia Information Network.

    Just wanted to alert others to this. I'm finding this side-effect too much to tolerate.
  2. Sasha

    Sasha Fine, thank you

    Actually, having read down the list on that dysautonomia site, there are quite a few things listed as possibly making OI worse that I think include types of sleep meds. The reference given for all but the last on the list is Grubb, B. P., & Karas, B. (1999). Clinical disorders of the autonomic nervous system associated with orthostatic intolerance: an overview of classification, clinical evaluation, and management. Pacing and Clinical Electrophysiology, 22, 798-810. Full text: Files/disorders.PDF

    Here's the list:

    Angiotensin Converting Enzyme Inhibitors
    Alpha Receptor Blockers
    Calcium Channel Blockers - Pregabalin/Lyrica is a calcium-channel blocker and I've been on it all year! Argh!
    Beta Blockers
    Tricyclic Antidepressants
    Ganglionic Blocking Agents
    Sildenafil Citrate
    MAO Inhibitors
  3. Sallysblooms

    Sallysblooms P.O.T.S. now SO MUCH BETTER!

    Southern USA
    I needed sleep back when my POTS strarted so I took natural things for sleep. They seemed to make me a bit worse, but I really needed the sleep back then. I took a teeny amount so it was no bad. Teeny.

    I sure found out out about diuretics! I was SOOOO sick after one tiny pill. My bp was bad so we tried that. Never again. Everyone is different, but I always start something new on a very small dose.
  4. SpecialK82

    SpecialK82 Ohio, USA

    Ohio, USA
    Sasha, thanks for posting, I have never heard that and I use melatonin every night. I would love to stop and see if my OI improves but I will have to find something else for my sleep first -- aack

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