Dear Dr Meglathery @stripey14), As you may know, I am a retired academic physician who advises charities on ME/CFS research and am on the board of directors here at PR. My work was in autoimmune disease but early on I got involved in hypermobility and associated systemic features. (For what it is worth I am not very convinced that there is a relation between hypermobility (or EDSIII) and ME/CFS and tenascin looks to be a very small part of the hypermobility story.) I have looked at your site and in particular the bit for scientists and your article draft. So far I am not clear why we should think so many different clinical problems should stem from these four associated genes. The article draft is not written in a scientific style - which basically means it is pretty hard to find the arguments. I appreciate your enthusiasm for initiating research into ME/CFS but I do wonder whether either you or Dr Herbst (who appears to specialise in fat disorders) are in a position to set up a viable study. I worry about that because you are asking for donations and you will be aware that PWME often are short of cash. I am sure your intentions are good but it is now so easy to ask for money over the internet that the dividing line between 'legit' and otherwise can get blurred. Would it not be wise to get positive feedback from an expert in the field before asking for donations?