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Medscape: Chronic Symptoms After HPV Vaccine: Part of Wider Syndrome?

natasa778

Senior Member
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1,774
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What is new in the latest report is the authors' speculation that the symptoms fit in with a recently described phenomenon known as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome).

The theory behind the syndrome suggests that heterogeneous postvaccination conditions, which are rare but have been chronicled among multiple individuals receiving different vaccines, might be the consequence of some immune dysfunction, putatively activated by the adjuvant rather than by the antigenic vaccine fraction, they note.

Long-Lasting Impairment

In the latest paper, a team led by Beniamino Palmieri, MD, from the University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy, report a series of 18 females (aged 12 to 24 years; mean age, 15.2 years) who were referred to the Second Opinion Medical Network for the evaluation of ''neuropathy with autonomic dysfunction'' after HPV vaccination.

These girls had received the HPV vaccine (9 with Gardasil [Merck & Co], 9 with Cervarix [GlaxoSmithKline]) when they were aged 11 to 12 years.

All the girls in this series reported long-lasting and invalidating somatoform symptoms (including asthenia, headache, cognitive dysfunction, myalgia, sinus tachycardia, and skin rashes), the Italian doctors report.

They add that the symptoms were consistent with severe fibromyalgia and chronic pain syndrome, according to the literature criteria.

"Because of these symptoms, at least 10 of these eighteen young girls developed a long-standing social impairment (school absence, sport suspension and daily activity impairment)," they comment.

"Previously, all these girls declared excellent fitness and wellness, including sport practice. No significant co-morbidities or previous relevant diseases were reported before the HPV immunization," they note....

http://www.medscape.com/viewarticle/867398

The article then added a detailed list of symptoms, on readers' request (see page 2 of the link above), concluding:


... among the most common and persistent symptoms, the girls reported memory and concentration impairment (n = 17), muscle pain (n = 13), finger and toe vascular abnormalities with skin color and temperature changes (n = 13), headache (n = 12), asthenia (n = 9), dizziness (n = 6), abdominal pain (n = 4), low-grade fever (n = 3), sinus tachycardia (n = 2), and skin rashes (n = 1).

... They comment that most of the girls showed an ''acute phase'' characterized by a variable combination of clinical manifestations, including low-grade fever, skin rashes, muscle pain, headache, and sensorial disturbances. Its onset occurred at a variable time after HPV immunization, ranging from hours to days.

"Then, this acute phase subsided in some weeks, but the girls developed some chronic and/or recurrent symptoms resembling chronic fatigue, fibromyalgia or other functional somatic syndromes. The clinical pictures displayed by each patient were actually polymorphous, except for asthenia, concentration problems, sensorial impairment (related to temperature perception, especially), recurrent or persisting muscle pain, paresis and headache," they comment.
 
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