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Medical Hypotheses: Autoimmunity in Post Lyme disease

Discussion in 'Lyme Disease and Co-Infections' started by jpcv, Jan 10, 2018.

  1. jpcv

    jpcv Senior Member

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    SE coast, Brazil
  2. Hip

    Hip Senior Member

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    So in summary, this autoimmune hypothesis of chronic Lyme says that:

    Borrelia burgdorferi enolase ➤ triggers autoimmune attack on gamma enolase in neurons ➤ blocks the brain's energy metabolism (as enolase is involved in glycolysis) ➤ causes the symptoms of chronic Lyme (such as brain fog, fatigue and pain).

    It is interesting to note that in primate studies, Borrelia burgdorferi have been shown to form a chronic antibiotic-resistant infections; so chronic Borrelia infections in Lyme patients could be constantly driving the autoimmune attack on gamma enolase.
     
    Mel9, MEMum and Isaiah 58:11 like this.
  3. jpcv

    jpcv Senior Member

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    Very interesting theory, I don't know much about Lyme because it's not a important disease where I live, nevertheless the similarities of symptoms with ME/cfs deserves some considerations that maybe some infectious agent caused some disturbance in the organism that can lead to a chronic disease (ME) even in the absence of active infection.
     
  4. Hip

    Hip Senior Member

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    That's a possibility, though it might also be possible that this autoimmune response hypothesized to cause chronic Lyme is being maintained by the constant presence of low levels of persistent infection.


    A similar infection-induced autoimmune theory for ME/CFS was proposed by Prof Peter Behan in the 1980s: he suggested that enterovirus may trigger an autoimmune attack on mitochondria that leads to ME/CFS. I wrote a thread on his autoimmune theory of ME/CFS.
     
    Last edited: Jan 10, 2018
    Mel9 and jpcv like this.

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