Hi there, I haven't posted on this site for quite some time. But I have been reading Hip's comprehensive thread on ME diagnosis, diagnostics and treatment approaches. I've also read recently an article on oxymatrine use to deal with Coxsackie B infection. I have been trying to find the root cause of my illness for the last 12 months, due to a deterioriation of symptoms including some new symptoms. I have positive blood tests from Armin Labs Germany for Borrelia Burg (lyme disease) and Coxsackie A, weak EBV, CMV and hsv1 active infections. These tests are contentious I realise and are also very sensitive but not very specific, which does argue, are they even worth taking seriously? Anyway I've taken them at face value. At the start of Sept I changed my diet to exclude almost all gluten, dairy and wheat (I have a little of each left in my diet, but at much smaller amounts than previously). I cut out all processed food and takeway food, including all processed sugar. I started a liver detox 3 x a day which consists of milk thistle, curcumin and dandelion now. I also take 3 or 4 anti viral tinctures and about 5 to 6 anti viral and bacterial/fungal capsules. Some of this is Buhner protocol, some of it is my own invention for immune boosting and inflamation reduction. I managed to become almost 100% symptom free last week, after taking the above 3x a day for 4 weeks. On the sunday just gone I decided to go to the sauna for about 15 minutes. This was steam room combined with a little Sauna. I felt a little dizzy afterwards and then deteriorated quickly from there. I find that my symptom picture deteriorates quickly after any excercise, or any type of mental or physical stress (even such as heat like the Sauna). I know other people get this. But after the sauna I was left with immediate stomach upset (bubbling in stomach for 2 days), fatigue for about 2 days, dizziness which has lessened but has not gone away and neurological issues of concentration, bad temper and poor mood (very depressed the first 2 days). I just wanted to ask if anyone else has linked adrenal, pituitary or thyroid problems to their ME? I ask because these are trickier to test for and I am now stuck as to which route to take with testing. At hte start of the year i started experiencing racing heartbeat at night and very bad dehydration. This dehydration almost stopped with plant based anti viral and anti bacterial treatment last week for about 2 weeks. However now my dehydration is back after PEM and it's very bad. I drank 3.2 litres today and my mouth is completely dry and my lips are the same. I have tried re-hydration salts with 2g sugar, this gave me aches and pains under my skin and through my body. So I don't think loss of salts is the issue. I have read HIP's post about other tests. ANA, Hypothyroidism and chronic lyme are the only potential root cuases. But I still can't help thinking it's an immune system problem, as until I started taking huge quantities of anti bacterials and anti virals I was getting ill all the time, in the winter htis consists of 6 months of being ill. I do still manage to work, but I really need to get my brain fog under control and my emotional outbursts, as it is effecting my work. I am not sure yet if I will get back to where I was a week ago feeling almost symptom free. Thanks.