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ME Study From Spain re Association of T and NK Cell Phenotypes with ME/CFS Diagnosis

Discussion in 'Latest ME/CFS Research' started by Wally, May 28, 2018.

  1. Wally

    Wally Senior Member

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  2. datadragon

    datadragon Guest

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    They were able to identify whether the people were ME/CFS patients or healthy and not sick in 70% of the cases using the observed differences in T and NK immune cells between patients and healthy controls. This can help in the diagnostic process of new ME/CFS patients, and help the recognition of the disease as it would have an objective measure. It would also help in the search of more specific treatments. They mention that more studies are needed to confim the findings and to contribute more info to establish the diagnosis criteria.
     
  3. lnester7

    lnester7 Seven

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    I remember in one of the Klimas videos and Peterson was there. That they think twice to give Cfs diagnosed if NK was normal. Some of the old Cfs specialist have been using Nk as one of the markers for a while.
     
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  4. AdamS

    AdamS Senior Member

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    This looks like a pretty good study, thanks for posting.

    CCC...good start!

    Interesting. I’m currently in a bit of a crash so can’t do much analysis, interested to hear what people think though!
     
  5. TreePerson

    TreePerson Senior Member

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    I tried looking at this but probably not well enough to understand it.

    I wasn’t clear whether they found that CD4 were higher or lower in pwme. I think they start by saying that previous studies have found higher levels in patients but I am not clear whether this was confirmed. I’m interested because I know mine are quite low.

    If anyone is well enough to explain the findings in very basic terms I would be really interested and grateful

    Edited. I meant CD4 not T4
     
    Last edited: Jun 6, 2018
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  6. Murph

    Murph :)

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    Certainly looks like they saw some real differences in some of the NK cells, as depcited in these charts.

    nk cells.jpg
    Figure 3. Analysis of NK cell subsets in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients (n = 76) and healthy subjects (n = 73). (A,B) NK cells as CD16+/−CD56+(dim) and CD16+/−CD56++(high) were obtained in gated CD45+ lymphocytes. (C–H) Percentages of NKG2C, NKG2A, NKp46, NKCD69, NKCD57, and ILT2 NK cells were obtained after gating for CD16+/−CD56+ lymphocytes. Figures show median values (lines), interquartile ranges (boxes), and 10–90 percentile values (bars). p Values obtained by Wilcoxon non-parametric test.
     
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  7. Murph

    Murph :)

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    Here's an interesting part of the discussion section

     
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