I'll be visiting the US next month and the time difference with where i'm currently staying is 12 hours! I usually deal with 6 hour jet lags and it takes me about a week to adjust. 12 hours is quite extreme for me so i need a solid plan on how to beat the lag! I was thinking about the following: - Try to adjust to the new time zone as close as possible for a few days before taking the trip, that means going to bed later. - Take melatonin before going to bed in the new timezone. - Flying business class so i can lay down flat and sleep. I can't sleep in an upright position and spending 22 hours in economy class with dysautonomia and ME is impossible! - Take a non-benzo sleep medication during the first days in the new timezone. - Book a hotel with very good noise isolation. Does anyone have any suggestions for a good non-benzo sleep med. to change the circadian rhythm? Herbs don't work, i need something solid. So far on my list are: Doxepin (TCA and anti-histamine) Remeron (TCA) Ambien (Z-drug) I also have a problem staying asleep, i wake up easily if disturbed by noise or light.