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Mast cell activation and autism

Discussion in 'Mast Cell Disorders/Mastocytosis' started by nanonug, Jul 18, 2012.

  1. nanonug

    nanonug Senior Member

    Virginia, USA


    Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by varying degrees of dysfunctional communication and social interactions, repetitive and stereotypic behaviors, as well as learning and sensory deficits. Despite the impressive rise in the prevalence of autism during the last two decades, there are few if any clues for its pathogenesis, early detection or treatment. Increasing evidence indicates high brain expression of pro-inflammatory cytokines and the presence of circulating antibodies against brain proteins. A number of papers, mostly based on parental reporting on their children's health problems, suggest that ASD children may present with "allergic-like" problems in the absence of elevated serum IgE and chronic urticaria. These findings suggest non-allergic mast cell activation, probably in response to environmental and stress triggers that could contribute to inflammation. In utero inflammation can lead to preterm labor and has itself been strongly associated with adverse neurodevelopmental outcomes. Premature babies have about four times higher risk of developing ASD and are also more vulnerable to infections, while delayed development of their gut-blood-brain barriers makes exposure to potential neurotoxins likely. Perinatal mast cell activation by infectious, stress-related, environmental or allergic triggers can lead to release of pro-inflammatory and neurotoxic molecules, thus contributing to brain inflammation and ASD pathogenesis, at least in a subgroup of ASD patients. This article is part of a Special Issue entitled: Mast cells in inflammation.
    Merry likes this.
  2. Sherlock

    Sherlock tart cherry etc. for joints, insomnia

    Czechosherlockia, USA
  3. Beyond

    Beyond Juice Me Up, Scotty!!!

    Murcia, Spain
    I think mast cells are huge in chronic disease, autism and CFS, even in CPPS!, but I also think their dysfunction at least in my case has been triggered - by heavy metals and other stressors. As it is recognised in that study, in fact. This leads us to the logical conclussion that mast cell problems arent a cause but a consequence. To actually recover we will need to get to the root, which its genetic mutations that are treatable, especially the methylation ones, those are the ones that leaded us to have a toxic body that gets inflammed and autoimmune and overeactive. Keep in mind oxidative stress causes mast cell activation. So leaky gut causes mast cell problems as well. MCAS Its not very deep into the rabbit hole IMO. Even if we have a genetic mutation causing our mast cells to be prone to dysfunction, lowering the oxidative stress etc from our bodies would make the situation better.

    I could be wrong. Time will tell because i´m addressing everything I can from leaky gut to methylation.
    camas likes this.

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