People with homozygous MAO SNP (MAO +/+) are deficient in monoamine oxidase. One old study revealed that in Schizophrenics, people with low levels of MAO activity, have elevated phosphatidylserine (PS) and decreased phosphatidylcholine (PC). The study mainly focuses on MAO B, which is not the one we get from Genetic Genie, but draws conclusion on an assumption that MAO B is related to total MAO activity level. The study's hypothesis was that PS inhibits MAO B, which lowers MAO activity, as seen in Schizophrenics. (1) This is highly debatable as another study shows that only MAO B is correlated to Schizophrenia. (2) On the other hand, there's another study showing that certain forms of PC can cause oxidative damage. Damaging reactions due to radicals generated in a membrane phase were significantly accelerated when the membrane was peroxidizable (soybean phosphatidylcholine) rather than nonperoxidizable (saturated dimyristoyl phosphatidylcholine). (3) Lastly, one study showed that metabolism of PC can lead to cardiovascular disease. I am not really sure how much more likely consumption of PC would lead to stroke or heart failure, but it is something worthwhile to consider. (4) Phospholipids are often praised as food for brain, which makes me think that it is strongly tied to neurotransmitters somehow. Unfortunately, I am not sure on a few things and hopefully I will get some responses! What is the relationship between phospholipids and neurotransmitters. Do phospholipids produce or help produce more neurotransmitters? I realize that PS and PC are two different lipids, but I do not know what effects each of them has on the brain. Based on the study I've quoted, I am guessing that PS and PC have opposite reactions to the brain. Is that assumption wrong? If PS is tied to serotonin, which neurotransmitter is PC tied to? I am just confused how low level of MAO can elevate PS while decreasing PC. How is PS tied to cortisol levels? I've seen mixed comments on PS and cortisol levels, depending on the state of the cortisol and the time PS is taken (morning vs evening). How is PC tied to cortisol levels? I couldn't find a consensus on this either. Lastly, if you have MAO ++, have you tried high doses of PS or PC? What effects did they have on you? I would sincerely appreciate feedback and responses to the question. Thank you so much in advance.