alex3619
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http://www.springerlink.com/content/g72153265k3t523j/
Metabolic Brain Disease
2012, DOI: 10.1007/s11011-012-9316-8
IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
Michael Maes, Ivana Mihaylova, Marta Kubera, Jean-Claude Leunis, Frank N. M. Twisk and Michel Geffard
Partially overlapping pathways, i.e. increased IgM antibodies to a multitude of neo-epitopes, underpin both ME/CFS and depression, while greater autoimmune responses directed against anchorage molecules and oxidatively modified neo-epitopes discriminate patients with ME/CFS from those with depression. These autoimmune responses directed against neoantigenic determinants may play a role in the dysregulation of key cellular functions in both disorders, e.g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression.
[source deleted pending clarification of citation]
Metabolic Brain Disease
2012, DOI: 10.1007/s11011-012-9316-8
IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
Michael Maes, Ivana Mihaylova, Marta Kubera, Jean-Claude Leunis, Frank N. M. Twisk and Michel Geffard
Partially overlapping pathways, i.e. increased IgM antibodies to a multitude of neo-epitopes, underpin both ME/CFS and depression, while greater autoimmune responses directed against anchorage molecules and oxidatively modified neo-epitopes discriminate patients with ME/CFS from those with depression. These autoimmune responses directed against neoantigenic determinants may play a role in the dysregulation of key cellular functions in both disorders, e.g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression.
[source deleted pending clarification of citation]