Discussion in 'Phoenix Rising Articles' started by Phoenix Rising Team, Mar 4, 2013.
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Thanks, Simon - another great article. We're lucky to have you explaining this stuff to us so clearly!
Excellent article, Simon! We are very fortunate to have brilliant researchers like Dr Hornig working on ME/CFS.
Thanks! And I agree we are really lucky to have people like Mady Hornig on the case, I think it's going to make a big difference. She's also seems genuinely concerned about patients, and willing to engage with them too. She was very good about answering quite a few detailed questions, and she will be speaking at this year's Invest in ME Conferernce in May - about her pathogen study.
"They infected mice with the same bacteria that cause strep throat and found obsessive-compulsive behaviour similar to that seen in humans (for mice it includes repeated back-flipping)."
I thought that was just me. Maybe that's why I'm so tired?
Thanks for the article Simon, I thought it was great, and really exciting how Mady Hornig works.
Thanks indeed SImon, i saw on the news in the last few days a new treatment for HIV - a pill they give patients for 2 weeks which causes the (?latent) virsus to emerge so they can they hit it.
Sorry do not recall more details sucha s name of drug or place ,...though i suspect it was in Australia. I saw it ont he evening news ulletin so likely the ABC.
That animation is absolutely brilliant! Great work.
Actually, Mady Hornig had a video clip of the mouse back flipping in her presentation but due to a technical glitch it wouldn't play
I saw that too, amazing stuff. Latency is a big reason they thought HIV could never be cured: as a retrovirus it integrates into your normal DNA - if its replicating drugs can block the replication and along with immune system can kill those cells too. If its latent and just sitting there in a dormant state it's completely safe, and can then reactivate later. Study was presented at the Retrovirus conference in Atlanta by an Oz professor, but hasn't been peer-reviewed or published yet.
I have to admit that I'm mightily impressed with Mady Hornig's approach.
Thanks Simon, great article! This is off-topic, but do you know if she's married ?
Personally I think, if she would find a pathogen, I think she would be able to solve many neurological conditions.
Mady Hornig quote
Mady Hornig has been it touch to say how pleased she was to have her work featured here, and also said this, which I quote with permission:
I was very touched by that.
Sorry, OS, can't help!
That's great - as a patient, I'm really delighted to hear that from a researcher.
Simon, do you have any idea how long the PANDAS research took? As in, was it months, years, or decades?
Thanks for another great article. I look forward to reading more of your work.
Thanks I think PANDAS work has gone on for decades, but I think Hornig's PANDAS work on mice was over a couple of years, but not really sure.
Thanks a lot Simon.
It made learning fun! It was really nice to read something informative that wasn't a challenge to get through. Looking forward to future articles.
Thanks - glad you enjoyed it. You should have seen the original talk: brilliant, but almost in Greek if you're a non-scientist. Will try to reduce everything to cartoon mice and pot-smoking where possible.
I'm grateful for the Beano version. Thanks a lot for working out how to translate her talk for the rest of us.
Thanks for the article. It's nice to know we have someone like that on our team !
Another Three Strikes example?
Waverunner has posted an interesting study looking at how genes can interact with maternal infection with a virus to increase the risk of Schizophrenia - a bit like the gene/pot-smoking/teen-start example Mady covered in her talk:.
Virus and Genes Involved in Causation of Schizophrenia
original paper here: http://www.nature.com/mp/journal/vaop/ncurrent/full/mp20132a.html
Simon: Thanks. Hornig seems to be a great scientist. In a few years, we all should be able to have whole genome sequencing done at a reasonable price. This will be a point, where a wave of new information will flood the medical field. Scientists like Hornig hopefully will benefit from this.
It can happen in teenagers and young adults also (the pandas or pans).
You can also try a Google Site Search
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