I was diagnosed with gulf war syndrome from serving in Iraq. Gulf War syndrome differs depending on the person. In my case I have fatigue, pain in my intercostal muscles, swollen cervical lymph nodes for years (had one removed), headaches, memory problems, stuff I actually learn I remember pretty well but incidental stuff during the day I can't remember for instance I know my daughters birthday but I don't remember being there when she was born, hives, pressure urticaria and more. All my tests have been normal. ANA several times, biopsies of skin and upper GI biopsysies and lymph node, every blood test known to man kind, tryptase. I have had so many work ups by so many specialists and nobody can come up with anything other then Gulf War Syndrome from exposures to chemicals or viruses in Iraq. OK...now that I've explained all that. My P.A. set me up today to try LDN. I have researched it over the last several months and it looks promising for my symptoms. My P.A. is very knowledgeable and up to date on alot of the less mainstream treatments. And she uses alot of natural treatments first. The problem I have is she told me that she has the best luck starting people out at 4.5 MG right off the bat. I asked her about all the problems I have read here with not starting at a lower dose and she said that she has many people on LDN and they all started at 4.5MG and had minimal side effects. I was an Army medic and I have alot of medical knowledge and I try to research treatments before I try them. What do you guys think about starting at 4.5mg likes she suggested?