Hi friends Could someone help me make sense of this and/or let me know if they have a similar pattern... My last set of blood tests showed low B cells and high antinuclear antibodies (dense fine speckled 1:2560). The antibodies have steadily climbed since I became sick (they were 1:80 this time last year). My immunology results are copied below. What I don’t understand is how these two test results line up - I though high B cells usually correlate with autoimmunity, because they’re producing the antibodies. I have bacterial and possibly viral infections, which means I need my B cells to be fighting them. My doctor indicated that my limited B cells are busy creating antibodies against my own body instead of dealing with the infections. Has anyone else come across this? We are now running more tests to try and figure out what the antibodies are attacking. Immunophenotyping CD3 (T cell-Total) 74 (range 58 - 84) CD4 (T Helper cells) 45 (30 - 61) CD8 (T Suppressor cells) 26 (12 - 45) CD3+CD4+CD8+ 1 CD3+CD4-CD8- 6 CD19 (B cells) 6 (6 - 22) CD16+56(NK cells) 19 (6 - 28) DR 10 CD3+DR+ 1 CD4/CD8 Ratio 1.73 (0.72 - 4.18) Lymphocytes 1400 x10^6/L (1200 - 4000) CD3 Absolute Numbers 1036 x10^6/L (805 - 2332) CD4 Absolute Numbers 630 x10^6/L (457 - 1498) CD8 Absolute Numbers 364 x10^6/L (205 - 1013) CD19 Absolute Numbers 84 L x10^6/L (93 - 480) Comments: CD45/SS Lymphocyte gating: Mild reduction in B cells noted.