I just came across some interesting articles about the T2 thyroid hormone (3,5 diiodo-L-thyronine), which is available as a supplement. T2 has the ability to boost the fat burning energy metabolism in mitochondria (as well as reduce mitochondrial oxidative stress). Refs: 1 2 3 4 Since Fluge and Mella's research showed that the glucose energy metabolism may be blocked in ME/CFS patients, boosting mitochondrial fat burning (an alternative route for deriving energy) might be a way to compensate for this blockage, and thus a T2 supplement could be beneficial in ME/CFS. Ron Davis thinks the glucose energy metabolism may be blocked in ME/CFS as well. Also, the fact that quite a few patients have reported substantial improvements on the ketogenic diet — a diet which increases mitochondrial fatty acid oxidation just as T2 does (see the study) — suggests that T2 could offer ME/CFS patients similar benefits to ketogenesis, without needing to follow the restrictions of a ketogenic diet. Here are excerpts from some T2 articles (note that these are marketing articles): Medical Information on T2: DIIODOTHYRONINE: Uses, Side Effects, Interactions and Warnings - WebMD T2 Supplement Brands: iFORCE TT-33 — £24 for 90 x 50 mcg capsules Antaeus labs: 3,5-T2 — £33 for 180 x 100 mcg capsules THYRO-T2 — $34 for 60 x 100 mcg capsules. RED BURNER — $32 for 90 capsules (but with the amount of T2 not specified). SAN Nutrition T2 Xtreme — £36 for 90 x 100 mcg capsules Note that some of these supplements contain T2 in the 3,3 diiodo-L-thyronine as well as the 3,5 diiodo-L-thyronine form. But apparently, only the 3,5 form has active effects.