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L Carnitine Fumarate and NAG problems?

Discussion in 'General ME/CFS Discussion' started by SuckSmoothie, Apr 18, 2016.

  1. SuckSmoothie

    SuckSmoothie

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    Hi all, I've recently started L-Carnitine Fumarate after hearing it was very important to the Krebs Cycle, for fatigue, and one of Freddds staples in the quartret, alongside N-acetyl glucosamine after reading about its anti-anxiety effects

    Recently it's all been the opposite: I've gotten more anxious, more fatigued, even after just waking up, less social, and less cognitively functional.

    I tried ALCAR in the past and reacted badly, I got symptoms of ACh dominance in the form of excess anxiety, slurring words, stuttering and mental retardation so I dropped it.

    Can I just be reacting badly to the LCF? or is it possible that the N-acetyl glucosamine's acetylation is causing ACh dominance?

    I'm not trying the methylation protocol since it gave me nasty anxiety, mental sluggishness and slurring. I'm using D-Ribose for Krebs cycle,vitamins A,C,E,K, p5p as the only b vit, molybdenum, iodine, zinc, magnesium, l-theanine and niacin every once in a while.

    @Freddd please check this out if you can
     
    Last edited: Apr 18, 2016
  2. Oberon

    Oberon Senior Member

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    In my opinion it's more likely the LCF causing the anxiety than the NAG. I would recommend dropping both and then adding back one at a time for a few weeks to assess their impact on you.
     
  3. SuckSmoothie

    SuckSmoothie

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    That's what I was thinking. I tried them both this morning before posting the thread, but after skipping the second dose I felt better. I'm just hoping someone can chime in on why.
     
  4. CCC

    CCC Senior Member

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    You might have tried too large a dose. If you're very sensitive to something, then you won't need much at all.

    Somewhere on PR, Freddd had advised people to get liquid LCF, start just a drop diluted in a glass of water, and slowly increase from there. It's the old 'start low and go slow' approach that many here advocate.
     
  5. SuckSmoothie

    SuckSmoothie

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    Maybe so, I started with half a cap of 855mg and worked up to the full pill in a week. I'll give it a shot in two weeks again
     
  6. CCC

    CCC Senior Member

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    We had to spend some time working UP to half a capsule a day, and we've never been able to take more.
     
  7. SuckSmoothie

    SuckSmoothie

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    Jeez, it's that strong? Or are you just very sensitive? I'm the sensitive type but I didn't start feeling some cognitive impairment until two or three days in, I wrongly attributed it to lack of sleep even though it might've played its part in my symptoms
     
  8. CCC

    CCC Senior Member

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    Many people need to start with much, much less.
     
  9. Oberon

    Oberon Senior Member

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    Presuming this study holds some validity to humans and carries to LCF it may explain some reasoning on why: http://www.ncbi.nlm.nih.gov/pubmed/22549035

    Increased norepinephrine and decrease GABA sounds like a good formula for anxiety to me.
     

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