Volunteer opportunity: Organizing Phoenix Rising articles
This section contains all the articles that have been published by Phoenix Rising over the years. As you will see if you browse here, some of the articles are outdated--either the research has been superseded or retracted or the article features an event or campaign that is now in...
Discuss the article on the Forums.

Is there a downside to really high dose Methylfolate besides over methylation?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by drob31, Oct 9, 2015.

  1. drob31

    drob31 Senior Member

    Messages:
    1,320
    Likes:
    796
    Assuming many of us are poor methylators and are compound heterozygous MTHFR, or homozygous MTHFR, what is the risk to trying to go really high on the methylfolate, like deplin doses? I just took 5 mg and feel pretty good, albeit slightly jittery. (I'm also taking meythyl b-12).
     
  2. GhostGum

    GhostGum Senior Member

    Messages:
    296
    Likes:
    314
    Vic, AU
    I personally can not even tolerate 1mg a day, I will end up flushing, feeling uncomfortable in my own skin and even developing eczema after a few days; meanwhile I love B12 and also seem to need extra B3. But I only have a minor homozygous MTHFR, while I have other homozygous which seem to need attention (signature).

    And why assume you are anything? Get your genes tested. You should probably also not take such large doses straight off the bat, go small, see how you go and work your way up. Methylation supplements are no quick fix, it takes time, and that is if it is an underlying factor for any given individual.
     
    helen1 likes this.
  3. ahmo

    ahmo Senior Member

    Messages:
    4,438
    Likes:
    6,792
    Northcoast NSW, Australia
    After some time at high doses (months, not years), my adrenals became stressed. This led me to discover that eating green veggies was blocking methylFolate. So I quit green veg, and reduced my need for folate by 50%. Then switched from swallowing to sublingual, and only needed 1/3 of what I'd been taking. In all, went from 30 mg to 5mg, and now stabilized at 2mg.
     
    Johnmac likes this.
  4. Aerose91

    Aerose91 Senior Member

    Messages:
    1,102
    Likes:
    632
    Im curious about this, too. I can take uo to 15 mg with no symptoms whatsoever- good or bad. Mb12 in maxed out at 10 right now so im not sure if its safe to just keep increasing the mfolate dose
     

See more popular forum discussions.

Share This Page