I was tested for most autoimmune diseases about a year ago. That would have been only a few months after the onset of fatigue. ANA was negative along with all other tests ordered. Since then, additional symptoms appeared such as a sore throat, dry eyes (I wear contacts and have never had a dry eyes problem in 20 years), and other evolutions of symptoms. Often a sore or dry throat in the morning. Also, my wrists are sometimes sore/stiff feeling -- in particular my right hand after using a trackpad, mouse, driving a long time, shaking it by practicing the african snap, etc. While we originally ruled out autoimmune diseases. However, is it necessary to retest a year later to be sure?