New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
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Is DMG safe long term?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by bigmillz, Feb 28, 2017.

  1. bigmillz

    bigmillz Senior Member

    I've been using TMG for a while, and wondering if it's starting to lower my energy levels a bit. This had happened last year, per my log. I'd like to try DMG, based on reading what Rich said about long term use of TMG being problematic for some:

    However, I found this while searching around:

    Not sure I trust this site. Most everything I've read here shows that DMG can be considered after TMG to move away from the BHMT pathway, once the "long route" is well supported.

    Thoughts on this? Has anyone moved from TMG to DMG and had positive results?
  2. aaron_c

    aaron_c Senior Member

    I've used both TMG and DMG, and they have seemed to work more or less as advertised; TMG increases SAMe and DMG seems to decrease SAMe--but only for an hour or maybe two.

    I think the concern of the second source you cited was that DMG, by slowing the BHMT enzyme, would decrease SAMe--and they don't want to do that too much.

    My take is that they've put the cart before the horse. While methylation is all well and good, Rich Van Konynenburg argued that problems with oxidation of folates and possibly B12 issues were the primary causes of the undermethylation seen in ME and possibly autism.'s suggestion to move to TMG and SAMe would slow down methionine synthase and potentially slow down the entire folic acid cycle, which is what Rich Van Konynenburg was concerned about in the first quote.

    TMG never lowered my energy, but it has caused problems focusing at one point. I figured it had something to do with cysteine deficiency--and maybe so--but DMG had the same effect. I ended up having to go off both and now take extra potassium or extra apple cider vinegar pills in order to get enough stomach acid to digest stuff.
    bigmillz and Oberon like this.
  3. bigmillz

    bigmillz Senior Member

    Thanks for the insight - I'm definitely leaning towards Rich's opinion on this, as I feel it's much better founded. doesn't seem to have a source or anything. Could be a typo/mixup for all we know.

    I'll give DMG a shot for a few weeks and see how I fare. If it's not positive, I'll try TMG again. I definitely seem to have more energy without TMG in the long term (short term, it's very energizing), but it definitely benefits my ability to focus as well staying on the TMG. I'm off it this week, and quite a bit more scatter brained.

    From what I've read too (mostly from Rich), TMG boosts SAMe, but the methionine synthase pathway should produce SAMe on its own anyways, when running properly.
    aaron_c likes this.
  4. Critterina

    Critterina Senior Member

    Arizona, USA
    My take is that it depends entirely on who you are. For me, TMG is good, DMG is bad, black and white. But in the methylation cycle, I there are two key enzymes, and you have two copies of the gene for each enzyme. I have the most serious mutations in all four genes. DMG slows the BHMT pathway because TMG is a reactant and DMG is a product. So, the fact that I'm sensitive (and believe me, I'm never taking DMG again!) probably means that I've very dependent on the second pathway, even when my B12/folate are well-supplemented.

    I think if your folate/B12 is working well, it might not matter as much. If you don't have both the MTRR A66G and BHMT-08 homozygous mutations, you probably don't stand a change of reacting like I did. If you do have them, it still may be 50/50.
    bigmillz likes this.
  5. cutie2u222


    My immune system has fallen, IGG and IGM because of low protein and coffee enemas. I have read where DMG will help both arms of the immune system and also help my B cells.

    Could I take this and just up my samE to offset the effects?

    Would that work. IGM is 31. Low normal is 48. Need help!

    Thank you,

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